研究成果

  • A Gata3 3′ distal otic vesicle enhancer directs inner ear-specific Gata3 expression. 
    Moriguchi T, Hoshino T, Rao A, Yu L, Takai J, Uemura S, Ise K, Nakamura Y, Lim KC, Shimizu R, Yamamoto M and Engel JD. 
    Mol Cell Biol. in press
  • Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer.
    Kishikawa T, Otsuka M, Suzuki T, Seimiya T, Sekiba K, Ishibashi R, Tanaka E, Ohno M, Yamagami M, Koike K.
    Mol Cancer Res in press. 

  • MicroRNA-7: A potent suppressor of the malignant potential of hepatocellular carcinoma.
    Otsuka M, Tanaka E, Sekiba K, Seimiya T, Yamagami M, Koike K. 
    Non-coding RNA Investig. in press.

  • HBV pathogenesis: Fresh insights into HBV RNA.
    Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K. 
    World J Gastroetenrol. in press.

  • DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels. 
    Sekiba K, Otsuka M, Ohno M, Kishikawa T, Yamagami M, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K.
    Oncotarget 2018; 9(39):20953-20964.

  • β-glucans in food modify colonic microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-dependent manner.
    Kamiya, T., Tang, C., Kadoki, M., Oshima, K., Hattori, M., Saijo, S., Adachi, Y., Ohno, N., and Iwakura, Y.
    Mucosal Immunol., 11, 763-773 (2018).

  • Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of intestinal microbiota.
    Tang, C., Kakuta, S., Shimizu, K., Kadoki, M., Kamiya, T., Shimazu, T., Kubo, S., Saijo, S., Ishigame, H., Nakae, S., and Iwakura, Y.
    Nature Immunol., 19, 755–765 (2018)

  • Effects of high fructose intake on liver injury progression in high fat diet induced fatty liver disease in ovariectomized female mice.
    T. Ohashi, M. Kato, A. Yamasaki, A. Kuwano, H. Suzuki, M. Kohjima, and Y. Ogawa. 
    Food Chem. Toxicol. 118: 190-197, 2018.

  • Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis.
    T. Goto, M. Itoh, T. Suganami, S. Kanai, I. Shirakawa, T. Sakai, M. Asakawa, T. Yoneyama, T. Kai, and Y. Ogawa.
    Sci. Rep. 8: e8157, 2018.

  • Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein.
    Yunoki K, Yoshinaga S, Takeda M, Nagano R, Tsuchiya Y, Sonoda A, Tsuji T, Hirakane M, Toda E, Terashima Y, Matsushima K, Terasawa H.
    Genes Cells. 2018;23(2):70-79.

  • Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T-cells mainly in the spleen.
    Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
    Int Immunol. 2018; 30(2):53-67.

  • Increased diversity with reduced “diversity evenness” of tumor infiltrating T-cells for the successful cancer immunotherapy.
    Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K.
    Sci Rep. 2018;8(1):1058.

  • Dysregulation of RNF213 promotes cerebral hypoperfusion. 
    Takaaki Morimoto, Jun-ichiro Enmi, Yorito Hattori, Satoshi Iguchi, Satoshi Saito, Kouji H. Harada, Hiroko Okuda, Yohei Mineharu, Yasushi Takagi, Shohab Youssefian, Hidehiro Iida, Susumu Miyamoto, Masafumi Ihara, Hatasu Kobayashi, Akio Koizumi
    Sci. Rep. 2018;8(1):3607.

  • NK cells control tumor-promoting function of neutrophils in mice.
    Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y.
    Cancer Immunol Res. 2018; 6(3):348-357.
  • The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion.
    Mojic M, Takeda K, Hayakawa Y.
    Int J Mol Sci. 2017;19(1). pii: E89.
  • Long-Lasting Graft-Derived Donor T Cells Contribute to the Pathogenesis of Chronic Graft-versus-Host Disease in Mice.
    Kosugi-Kanaya M, Ueha S, Abe J, Shichino S, Shand FHW, Morikawa T, Kurachi M, Shono Y, Sudo N, Yamashita A, Suenaga F, Yokoyama A, Yong W, Imamura M, Teshima T, Matsushima K.
    Front Immunol. 2017;8:1842.
  • The HIV co-receptor CCR5 regulates osteoclast function.
    Ji-Won Lee, Akiyoshi Hoshino, Kazuki Inoue, Takashi Saitou, Shunsuke Uehara6, Yasuhiro Kobayashi, Satoshi Ueha, Kouji Matsushima, Akira Yamaguchi, Yuuki Imai and Tadahiro Iimura,
    Nature communication. 2017;8(1):2226
  • SREBP-regulated lipid metabolism: convergent physiology – divergent pathophysiology.
    Shimano H., Sato R.
    Nat Rev Endocrinol. 2017;13(12):710-730.
  • Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter.
    Ohsako S, Aiba T, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K, Kojima Y.
    Arch Environ Contam Toxicol. 2018;74(2):240-247.
  • The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells.
    Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S.
    Eur J Immunol. 2017; 47(12):2163-2174.
  • ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.
    Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H.
    Cell Death Differ.  2017; 24(12):2066-2076.
  • RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease.
    Matsuda Y, Mineharu Y, Kimura M, Takagi Y, Kobayashi H, Hitomi T, Harada KH, Uchihashi Y, Funaki T, Miyamoto S, Koizumi A.
    J Stroke Cerebrovasc Dis. 2017;26(8):1841-1847.
  • Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.
    Sawada Y, Izumida Y, Takeuchi Y, Aita Y, Wada N, Li E, Murayama Y, Piao X, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Kadowaki T, Shimano H, Yahagi N.
    Biochem Biophys Res Commun. 2017; 493(1):40-45.
  • Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity.
    Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H.
    Diabetes. 2017; 66(7): 1833-1846.
  • Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B.
    Nosaka T, Naito T, Hiramatsu K, Ohtani M, Nemoto T, Marusawa H, Ma N, Hiraku Y, Kawanishi S, Yamashita T, Kaneko S, Nakamoto Y.
    PLoS One. 2017;12(10):e0185442.
  • Ribosomal protein S3 regulates XIAP expression independently of the NF-kB pathway in breast cancer cells.
    Ono H, Iizumi Y, Goi W, Sowa Y, Taguchi T, Sakai T. 
    Oncol Rep. 2017; 38(5): 3205-3210.
  • Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis and Cisplatin Resistance of Lung Cancer Cells.
    Endo S, Xia S, Suyama M, Morikawa Y, Oguri H, Hu D, Ao Y, Takahara S, Horino Y, Hayakawa Y, Watanabe Y, Gouda H, Hara A, Kuwata K, Toyooka N, Matsunaga T, Ikari A.
    J Med Chem. 2017;60(20):8441-8455.
  • Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma.
    Xu X, Yokoyama S, Hayakawa Y, Saiki I.
    Oncol Rep. 2017;38(1):538-544.
  • Proteasome Inhibitor-Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-κB Inhibition.
    Wu H, Tao A, Martin JD, Quader S, Liu X, Takahashi K, Hespel L, Miura Y, Hayakawa Y, Irimura T, Cabral H, Kataoka K.
    J Pharm Sci. 2017;106(9):2438-2446.
  • Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant.
    Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health, Azuma K, Endo G, Endo Y, Fukushima T, Hara K, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara G, Ikeda M, Ishitake T, Ito A, Ito Y, Iwasawa S, Kamijima M, Karita K, Katoh T, Kawai T, Kawamoto T, Kishi R, Kumagai S, Kusaka Y, Matsumoto A, Miyagawa M, Miyauchi H, Morimoto Y, Nagano K, Naito H, Nakajima T, Nomiyama T, Okuda H, Omae K, Sakurai H, Sato K, Sobue T, Suwazono Y, Takebayashi T, Takeshita T, Takeuchi A, Takeuchi A, Tanaka M, Tanaka S, Tsukahara T, Tsunoda M, Ueno S, Ueyama J, Umeda Y, Yamano Y, Yamauchi T, Yano E.
    J Occup Health. 2017;59(4):364-366.
  • Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells.
    Kim JH, Kurtz A, Yuan BZ, Zeng F, Lomax G, Loring JF, Crook J, Ju JH, Clarke L, Inamdar MS, Pera M, Firpo MT, Sheldon M, Rahman N, O’Shea O, Pranke P, Zhou Q, Isasi R, Rungsiwiwut R, Kawamata S, Oh S, Ludwig T, Masui T, Novak TJ, Takahashi T, Fujibuchi W, Koo SK, Stacey GN.
    Stem Cells Transl Med. 2017;6(11):1956-1962.
  • Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor-binding protein 2 in renal cell carcinoma.
    Katayama H, Tamai K, Shibuya R, Nakamura M, Mochizuki M, Yamaguchi K, Kawamura S, Tochigi T, Sato I, Okanishi T, Sakurai K, Fujibuchi W, Arai Y, Satoh K.
    Scientific Reports 2017;7(1):12016.
  • Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres.
    Iki T, Tanaka M, Kitajiri SI, Kita T, Kawasaki Y, Mizukoshi A, Fujibuchi W, Nakagawa T, Nakahata T, Ito J, Omori K, Saito MK.
    PLOS ONE. 2017;12(6):e0179901, 2017.
  • Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues.
    Hashimoto S, Tabuchi Y, Yurino H, Hirohashi Y, Deshimaru S, Asano T, Mariya T, Oshima K, Takamura Y, Ukita Y, Ametani A, Kondo N, Monma N, Takeda T, Misu S, Okayama T, Ikeo K, Saito T, Kaneko S, Suzuki Y, Hattori M, Matsushima K, Torigoe T.
    Sci Rep. 2017 Oct 27;7(1):14225.
  • Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function.
    Kurachi M, Kurachi J, Chen Z, Johnson J, Khan O, Bengsch B, Stelekati E, Attanasio J, McLane LM, Tomura M, Ueha S, Wherry EJ.
    Nat Protoc. 2017;12(9):1980-1998.
  • Combination of anti-CD4 antibody treatment and donor lymphocyte infusion ameliorates graft-versus-host disease while preserving graft-versus-tumor effects in murine allogeneic hematopoietic stem cell transplantation.
    Ueha S, Yokochi S, Ishiwata Y, Kosugi-Kanaya M, Shono Y, Shibayama S, Ito S, Matsushima K.
    Cancer Sci. 2017;108(10):1967-1973.
  • 組織からの1細胞分取
    橋本真一、上羽悟史
    実験医学別冊 シングルセル解析プロトコール2017年9月号 p102-106
  • Nx1-seq マイクロウェルプレートを用いた1細胞遺伝子発現解析
    橋本真一
    実験医学別冊 シングルセル解析プロトコール、2017年9月号 p171-175