研究成果

  • CCR5, a co-receptor of HIV, is required for the functional cellular architecture of osteoclasts, thereby elucidating the direct association between loss of CCR5 and resistance to bone loss in mice
    Ji-Won Lee, Akiyoshi Hoshino, Kazuki Inoue, Takashi Saitou, Shunsuke Uehara6, Yasuhiro Kobayashi, Satoshi Ueha, Kouji Matsushima, Akira Yamaguchi, Yuuki Imai and Tadahiro Iimura,
    Nature communication. 2017 in press.
  • SREBP-regulated lipid metabolism: convergent physiology – divergent pathophysiology.
    Shimano H., Sato R.
    Nat Rev Endocrinol. 2017 in press.
  • Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter.
    Ohsako S, Aiba T, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K, Kojima Y.
    Arch Environ Contam Toxicol. 2017 in press.
  • The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells.
    Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S.
    Eur J Immunol. 2017 in press.
  • ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.
    Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H.
    Cell Death Differ. 2017 in press
  • RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease.
    Matsuda Y, Mineharu Y, Kimura M, Takagi Y, Kobayashi H, Hitomi T, Harada KH, Uchihashi Y, Funaki T, Miyamoto S, Koizumi A.
    J Stroke Cerebrovasc Dis. 2017;26(8):1841-1847.
  • Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.
    Sawada Y, Izumida Y, Takeuchi Y, Aita Y, Wada N, Li E, Murayama Y, Piao X, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Kadowaki T, Shimano H, Yahagi N.
    Biochem Biophys Res Commun. 2017; 493(1):40-45.
  • Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity.
    Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H.
    Diabetes. 2017; 66(7): 1833-1846.
  • Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B.
    Nosaka T, Naito T, Hiramatsu K, Ohtani M, Nemoto T, Marusawa H, Ma N, Hiraku Y, Kawanishi S, Yamashita T, Kaneko S, Nakamoto Y.
    PLoS One. 2017;12(10):e0185442.
  • Ribosomal protein S3 regulates XIAP expression independently of the NF-kB pathway in breast cancer cells.
    Ono H, Iizumi Y, Goi W, Sowa Y, Taguchi T, Sakai T. 
    Oncol Rep. 2017; 38(5): 3205-3210.
  • Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis and Cisplatin Resistance of Lung Cancer Cells.
    Endo S, Xia S, Suyama M, Morikawa Y, Oguri H, Hu D, Ao Y, Takahara S, Horino Y, Hayakawa Y, Watanabe Y, Gouda H, Hara A, Kuwata K, Toyooka N, Matsunaga T, Ikari A.
    J Med Chem. 2017;60(20):8441-8455.
  • Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma.
    Xu X, Yokoyama S, Hayakawa Y, Saiki I.
    Oncol Rep. 2017;38(1):538-544.
  • Proteasome Inhibitor-Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-κB Inhibition.
    Wu H, Tao A, Martin JD, Quader S, Liu X, Takahashi K, Hespel L, Miura Y, Hayakawa Y, Irimura T, Cabral H, Kataoka K.
    J Pharm Sci. 2017;106(9):2438-2446.
  • Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant.
    Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health, Azuma K, Endo G, Endo Y, Fukushima T, Hara K, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara G, Ikeda M, Ishitake T, Ito A, Ito Y, Iwasawa S, Kamijima M, Karita K, Katoh T, Kawai T, Kawamoto T, Kishi R, Kumagai S, Kusaka Y, Matsumoto A, Miyagawa M, Miyauchi H, Morimoto Y, Nagano K, Naito H, Nakajima T, Nomiyama T, Okuda H, Omae K, Sakurai H, Sato K, Sobue T, Suwazono Y, Takebayashi T, Takeshita T, Takeuchi A, Takeuchi A, Tanaka M, Tanaka S, Tsukahara T, Tsunoda M, Ueno S, Ueyama J, Umeda Y, Yamano Y, Yamauchi T, Yano E.
    J Occup Health. 2017;59(4):364-366.
  • Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells.
    Kim JH, Kurtz A, Yuan BZ, Zeng F, Lomax G, Loring JF, Crook J, Ju JH, Clarke L, Inamdar MS, Pera M, Firpo MT, Sheldon M, Rahman N, O’Shea O, Pranke P, Zhou Q, Isasi R, Rungsiwiwut R, Kawamata S, Oh S, Ludwig T, Masui T, Novak TJ, Takahashi T, Fujibuchi W, Koo SK, Stacey GN.
    Stem Cells Transl Med. 2017;6(11):1956-1962.
  • Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor-binding protein 2 in renal cell carcinoma.
    Katayama H, Tamai K, Shibuya R, Nakamura M, Mochizuki M, Yamaguchi K, Kawamura S, Tochigi T, Sato I, Okanishi T, Sakurai K, Fujibuchi W, Arai Y, Satoh K.
    Scientific Reports 2017;7(1):12016.
  • Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres.
    Iki T, Tanaka M, Kitajiri SI, Kita T, Kawasaki Y, Mizukoshi A, Fujibuchi W, Nakagawa T, Nakahata T, Ito J, Omori K, Saito MK.
    PLOS ONE. 2017;12(6):e0179901, 2017.
  • Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues.
    Hashimoto S, Tabuchi Y, Yurino H, Hirohashi Y, Deshimaru S, Asano T, Mariya T, Oshima K, Takamura Y, Ukita Y, Ametani A, Kondo N, Monma N, Takeda T, Misu S, Okayama T, Ikeo K, Saito T, Kaneko S, Suzuki Y, Hattori M, Matsushima K, Torigoe T.
    Sci Rep. 2017 Oct 27;7(1):14225.
  • Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function.
    Kurachi M, Kurachi J, Chen Z, Johnson J, Khan O, Bengsch B, Stelekati E, Attanasio J, McLane LM, Tomura M, Ueha S, Wherry EJ.
    Nat Protoc. 2017;12(9):1980-1998.
  • Combination of anti-CD4 antibody treatment and donor lymphocyte infusion ameliorates graft-versus-host disease while preserving graft-versus-tumor effects in murine allogeneic hematopoietic stem cell transplantation.
    Ueha S, Yokochi S, Ishiwata Y, Kosugi-Kanaya M, Shono Y, Shibayama S, Ito S, Matsushima K.
    Cancer Sci. 2017;108(10):1967-1973.
  • 組織からの1細胞分取
    橋本真一、上羽悟史
    実験医学別冊 シングルセル解析プロトコール2017年9月号 p102-106
  • Nx1-seq マイクロウェルプレートを用いた1細胞遺伝子発現解析
    橋本真一
    実験医学別冊 シングルセル解析プロトコール、2017年9月号 p171-175