研究成果

2019年

  • Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, is a potent inhibitor of hepatitis B virus.
    Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Seimiya T, Suzuki T, Tanaka E, Ishibashi R, Funato K, and Koike K.
    Hepatology 2019 in press.
  • Nakagomi R, Tateishi R, Masuzaki R, Soroida Y, Iwai T, Kondo M, Fujiwara N, Sato M, Minami T, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Tanaka Y, Otsuka M, Kato N, Moriya K, Ikeda H, Koike K. Liver stiffness measurements in chronic hepatitis C: treatment evaluation and risk assessment J Gastroenterol Hepatol. 2019 in press.
  • Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.
    Nishimura K(co-first authors), Johmura Y (co-first authors), Deguchi K, Jiang Z, Uchida K, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura S, Kono K, Nakanishi M.
    Nature Communications. 2019 in press.
  • Identification and isolation of splenic tissue resident macrophage subpopulations by flow cytometry.
    Fujiyama S, Nakahashi-Oda C, Abe F, Wang Y, Sato K, Shibuya A.
    Int Immunol. 2019;31(1):51-56.
  • Serum aldo–keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis.
    Kanno M, Kawaguchi K, Honda M, Horii R, Takatori H, Shimakami T, Kitamura K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
    J Gastroenterol. 2019 Feb 1. doi: 10.1007/s00535-019-01551-3.
  • The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.
    Müller CP, Chu C, Qin L, Liu C, Xu B, Gao H, Ruggeri B, Hieber S, Schneider J, Jia T, Tay N, Akira S, Satoh T, Banaschewski T, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Artiges E, Lemaitre H, Nees F, Papadopoulos Orfanos D, Paus T, Poustka L, Millenet S, Fröhner JH, Smolka MN, Walter H, Whelan R, Bakalkin G, Liu Y, Desrivières S, Elliott P, Eulenburg V, Levy D, Crews F, Schumann G.
    Cereb Cortex. 2019 Feb 4. [Epub ahead of print]
  • TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity.
    Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N.
    Dev Cell. 2019 Jan 28;48(2):151-166.e7.
  • Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice.
    Brenner D, Sieverding K, Bruno C, Lüningschrör P, Buck E, Mungwa S, Fischer L, Brockmann SJ, Ulmer J, Bliederhäuser C, Philibert CE, Satoh T, Akira S, Boillée S, Mayer B, Sendtner M, Ludolph AC, Danzer KM, Lobsiger CS, Freischmidt A, Weishaupt JH.
    J Exp Med. 2019 Feb 4;216(2):267-278.
  • USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation.
    Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, He Z, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T, Matsuura Y.
    J Virol. 2019 Jan 9. pii: JVI.01708-18.
  • Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.
    Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
    Exp Mol Pathol. 2019 Feb;106:78-88.
  • *Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema.
    Kazushige Shiraishi, Shigeyuki Shichino, Tatsuya Tsukui, Shinichi Hashimoto, Satoshi Ueha, and Kouji Matsushima
    Sci Rep. in press. 2019.
  • Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice. Chen CY, Ueha S, Ishiwata Y, Yokochi S, Yang D, Oppenheim JJ, Ogiwara H, Shichino S, Deshimaru S, Shand FH, Shibayama S, Matsushima K.
    J Immunother. in press, 2019.
  • A dendritic cell-based systemic vaccine induces long-lived lung-resident memory Th17 cells and ameliorates pulmonary mycosis.
    Ueno, K., Urai, M., Sadamoto, S., Shinozaki, M., Takatsuka, S., Abe, M., Otani, Y., Yanagihara, N., Shimizu, K., Iwakura, Y., Shibuya, K., Miyazaki, Y., and Kinjo, Y.
    Mucosal Immunol., 12, 265-276 (2019).
  • Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells.
    Yamada T, Nabe S, Toriyama K, Inoue K, Imai Y, Shiraishi A, Takenaka K, Yasukawa M, Yamashita M.
    J. Immunol. 202: 1088-1098. (2019)
  • Toxicological Evaluation of SiO₂ Nanoparticles by Zebrafish Embryo Toxicity Test.
    Vranic S, Shimada Y, Ichihara S, Kimata M, Wu W, Tanaka T, Boland S, Tran L, Ichihara G.
    Int J Mol Sci. 2019 Feb 18;20(4)
  • Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation.
    Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, Miura K, Ueshima H, Komuro I, Yamagishi M, Horie M, Kawakami K, Furukawa T, Koizumi A, Kurachi Y, Sakata Y, Minamino T, Kitakaze M, Takashima S.
    Circulation. 2019 Feb 15. doi: 10.1161/CIRCULATIONAHA.118.036761. [Epub ahead of print]
  • *Characteristics of Japanese Patients with Nonvalvular Atrial Fibrillation on Anticoagulant Treatment: A Descriptive Analysis of J-dabigatran Surveillance and JAPAF Study.
    Koretsune Y, Kusakawa K, Harada KH, Koizumi A, Uchiyama S, Atarashi H, Okumura K, Yasaka M, Yamashita T, Taniguchi A, Fukaya T, Inoue H; for J-dabigatran surveillance and JAPAF study investigators.
    Cardiol Ther. 2019 Feb 11. doi: 10.1007/s40119-019-0129-2. [Epub ahead of print]
  • *Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis.
    Okazaki S, Morimoto T, Kamatani Y, Kamimura T, Kobayashi H, Harada K, Tomita T, Higashiyama A, Takahashi JC, Nakagawara J, Koga M, Toyoda K, Washida K, Saito S, Takahashi A, Hirata M, Matsuda K, Mochizuki H, Chong M, Paré G, O’Donnell M, Ago T, Hata J, Ninomiya T, Dichgans M, Debette S, Kubo M, Koizumi A, Ihara M.
    Circulation. 2019 Jan 8;139(2):295-298.
  • Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex.
    Murayama Y, Yahagi N, Takeuchi Y, Aita Y, Mehrazad Saber Z, Wada N, Li E, Piao X, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Miyamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.
    FEBS Lett. 2019 Jan 19. [Epub ahead of print]
  • Role of eosinophils in a murine model of inflammatory bowel disease.
    Wang Z, Adachi S, Kong L, Watanabe D, Nakanishi Y, Ohteki T, Hoshi N, Kodama Y.
    Biochem Biophys Res Commun 2019 doi: 10.1016/j.bbrc.2019.02.056. [Epub ahead of print]
  • Transcriptome network analysis identifies protective role of the LXR-SREBP-1c axis in murine pulmonary fibrosis
    Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, Kosugi-Kanaya M, Shand FH, Inagaki Y, Shimano H, Matsushima K
    JCI Insight. 2019 Jan 10;4(1)). pii: 122163. doi: 10.1172/jci.insight.122163.

2018年

  • Yamagami M, Otsuka M, Kishikawa T, Sekiba K, Seimiya T, Tanaka E, Suzuki T, Ishibashi R, Ohno M, Koike K. ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells.
    npj Aging Mech Dis. 2018;15;4:11.
  • *Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K.Inhibition of HBV transcription from cccDNA with nitazoxanide by targeting the HBx–DDB1 interaction.
    Cell Mol Gastroenterol Hepatol. 2018;7(2):297-312.
  • Inflammation and de-differentiation in pancreatic carcinogenesis.
    Seimiya T, Otsuka M, Iwata T, Tanaka E, Suzuki T, Sekiba K, Yamagami M, Ishibashi R, Koike K.
    World J Clin Cases. 2018;6(15):882-891.
  • TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity.
    Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N.
    Dev. Cell 2018;48(2):151-166.
  • Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction.
    Lee SJ, Lee CK, Kang S, Park I, Kim YH, Kim SK, Hong SP, Bae H, He Y, Kubota Y, Koh GY.
    J. Clin. Invest. 2018;128:5018-5033.
  • Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.
    Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, Iwama A.
    Exp. Hematol. 2018;63:41-51.
  • Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.
    Nakayama, S., Yumimoto, K., Kawamura, A., Nakayama, K. I.
    J. Biol. Chem., 293(15), 5705-5714, (2018).
  • *Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies.
    Negoro R, Takayama K, Kawai K, Harada K, Sakurai F, Hirata K, Mizuguchi H.
    Stem Cell Reports. 2018 Dec 11;11(6):1539-1550.
  • Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
    Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
    J Clin Invest. 2018 Dec 3;128(12):5603-5619.
  • Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.
    Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
    Cereb Cortex. 2018 Oct 11.
  • Ishimoto, Y., Ishibashi, K. I., Yamanaka, D., Adachi, Y., Kanzaki, K., Iwakura, Y., and Ohno, N. Production of low-molecular weight soluble yeast b-glucans by an acid degradation method.
    Int. J. Biol. Macromol., 107, 2269-2278 (2018).
  • IL-R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota.
    Yoshida, K., Murayama, M. A., Shimizu, K., Tang, C., Katagiri, N., Matsuo, K., Fukai, F., and Iwakura, Y.
    Biochem. Biophys. Res. Commun., 496, 934-940 (2018).
  • HER2 overexpression triggers an IL-1α pro-inflammatory circuit to drive tumorigenesis and promote chemotherapy resistance.
    Liu, S., Lee, J. S., Jie, C., Park, M. H., Iwakura, Y., Patel, Y., Soni, M., Reisman, D., and Chen, H.
    Cancer Res., 78, 2040-2051 (2018).
  • Establishment and analysis ofa novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.
    Ikenoue, T., Terakado, Y., Zhu, C., Liu, X., Ohsugi, T., Matsubara, D., Fujii, T., Kakuta, S., Kubo, S., Shibata, T., Yamaguchi, K., Iwakura, Y., and Furukawa, Y.
    Sci. Rep., 8, 2021(2018).
  • Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κB addiction in malignant pleural effusion.
    Marazioti, A., Lilis, I., Vreka, M., Apostolopoulou, H., Kalogeropoulou, A., Giopanou, I., Giotopoulou, G. A., Krontira, A. C., Iliopoulou, M., Kanellakis, N. I., Agalioti, T., Giannou, A. D., Jones-Paris, C., Iwakura, Y., Kardamakis, D., Blackwell, T. S., Taraviras, S., Spella, M., and Stathopoulos, G. T.
    Nat. Commun., 9, 672 (2018).
  • Host defense against oral microbiota by bone-damaging T cells.
    Tsukasaki, M., Komatsu, N., Nagashima, K., Nitta, T., Pluemsakunthai, W., Shukunami, C., Iwakura, Y., Nakashima, T., Okamoto, K., and Takayanagi, H.
    Nat. Commun., 9, 701 (2018).
  • Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α deficient B cells.
    Zhu, G., Liu, X., Fang, Y., Zhai, B., Xu, R., Han, G., Chen, G., Xiao, H., Hou, C., Shen, B., Li, Y., Iwakura, Y., Wang, L., Jiang, Z., Ma, N., Liu, G., and Wang, R.
    Cell. Immunol., 328, 9-17 (2018).
  • IL-25 enhances Th17 cell-mediated contact dermatitis by promoting IL-1β production by dermal dendreitic cells.
    Suto, H., Nambu, A., Morita, H., Yamaguchi, S., Numata, T., Yoshizaki, T., Shimura, E., Arae, K., Asada, Y., Motomura, K., Kaneko, M., Abe, T., Matsuda, A., Iwakura, Y., Okumura, K., Saito, H., Matsumoto, K., Sudo, K., and Nakae, S.
    J. Allergy Clin. Immunol., 142, 1500-1509 (2018).
  • Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells.
    Tong, H., Miyake, Y., Mi-Ichi, F., Iwakura, Y., Hara, H., and Yoshida, H.
    PLoS One,, 13, e0195119 (2018).
  • A model of Th17-associated ileal hyperplasia that requires both IL-17A and IFN-γ to generate self-tolerance and prevent colitis.
    Jeschke, J. C., Mayne, C. G., Ziegelbauer, J., DeCiantis, C. L., Singh, S., Kumar, S. N., Suchi, M., Iwakura, Y., Drobyski, W. R., Salzman, N. H., and Williams, C. B.
    Mucosal Immunol., 11, 1127-1137 (2018).
  • IL-36α from skin-resident cells plays an important role in the pathogenesis of imiquimod-induced psoriasiform dermatitis by forming a local autoamplification loop.
    Hashiguchi, Y., Yabe, R., Chung, S. H., Murayama, M. A., Yoshida, K., Matsuo, K., Kubo, S., Saijo, S., Nakamura, Y., Matsue, H., and Iwakura, Y.
    J. Immunol., 201, 167-182 (2018).
  • Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation.
    Isoda, K., Akita, K., Kitamura, K., Sato-Okabayashi, Y., Kadoguchi, T., Isobe, S., Ohtomo, F., Sano, M., Shimada, K., Iwakura, Y., and Daida, H.
    Int. J. Cardiol., 270, 221-227 (2018).
  • BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance.
    Matsushita, T., Kobayashi, T., Mizumaki, K., Kano, M., Sawada, T., Tennichi, M., Okamura, A., Hamaguchi, Y., Iwakura, Y., Hasegawa, M., Fujimoto, M., and Takehara, K.
    Sci. Adv., 4, eaas9944 (2018).
  • Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model.
    Shibue, Y., Kimura, S., Kajiwara, C., Iwakura, Y., Yamaguchi, K., and Tateda, K.
    Microbes Infect., (2018).
  • MAIT cells protect agaist pulmonary Legionella longbeaches infection.
    Wang, H., D’Souza, C., Lim, X. Y., Kostenko, L., Pediongco, T. J., Eckle, S. B. G., Meehan, B. S., Shi, M., Wang, N,., Li, S., Liu, L., Mak, J. Y. W., Fairlie, D. P, Iwakura, Y., Gunnersen, J. M., Stent, A. W., Godfrey, D. I., Rossjohn, J., Westall, G. P., Kjer-Nielsen, L., Strugnell, R. A., McCluskey, J., Corbett, A. J., Hinks, T. S. C., and Chen, Z.
    Nat. Commun., 9, 3350 (2018).
  • The ATP transporter VNUT mediates induction of Dectin-1-triggered candida nociception.
    Maruyama, K., Takayama, Y., Sugisawa, E., Yamanoi, Y., Yokawa, T., Kondo, T., Ishibashi, K. I., Sahoo, B. R., Takemura, N., Mori, Y., Kanemaru, H., Kumagai, Y., Martino, M. M., Yoshioka, Y., Nishijo, H., Tanaka, H., Sasaki, A., Ohno, N., Iwakura, Y., Moriyama, Y., Nomura, M., Akira, S., Tominaga, M.
    iScience, 6, 306-318 (2018).
  • IL-36a is involved in hepten-specific T-cell induction, but not local inflammation, during contact hypersensitivity.
    Numata, T., Yoshizaki, T., Yamaguchi, S., Shimura, E., Iwakura, Y., Harada, K., Sudo, K., Tsuboi, R., and Nakae, S.
    Biochem. Biophys. Res. Commun., 506, 429-436 (2018).
  • IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse.
    Oike, T., Kanagawa, H., Sato, Y., Kobayashi, T., Nakatsukasa, H., Miyamoto, K., Nakamura, S., Kaneko, Y., Kobayashi, S., Harato, K., Yoshimura, A., Iwakura, Y., Takeuchi, T., Matsumoto, M., Nakamura, M., Niki, Y., and Miyamoto, T.
    Sci. Rep., 8, 15783 (2018).
  • TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.
    Zhang, C. J., Jiang, M., Zhou, H., Liu, W., Wang, C., Kang, Z., Han, B., Zhang, Q., Chen, X., Xiao, J., Fisher, A., Kaiser, W. J., Murayama, M. A., Iwakura, Y., Gao, J., Carman, J., Dongre, A., Dubyak, G., Abbott, D. W., Shi, F. D., Ransohoff, R. M., and Li, X.
    J. Clin. Invest., 128, 5399-5412 (2018).
  • Dectin-2-mediated signaling leads to delayed skin wound healing through enhanced neutrophilic inflammatory response and neutrophil extracellular traps formation.
    Miura, T., Kawakami, K., Kanno, E., Tanno, H., Tada, H., Sato, N., Masaki, A., Yokoyama, R., Kawamura, K., Kitai, Y., Takagi, N., Yamaguchi, K., Yamaguchi, N., Kyo, Y., Ishii, K., Imai, Y., Saijo, S., Iwakura, Y., and Tachi, M.
    J. Invest. Dermatol., (2018).
  • Dectin-1 contributes to myocardial ischemia-reperfusion injury by regulating macrophage polarization and neutrophil infiltration.
    Fan, Q., Tao, R., Zhang, H., Xie, H., Lu, L., Wang, T., Su, M., Hu, J., Zhang, Q., Chen, Q., Iwakura, Y., Shen, W., Zhang, R., and Yan, X.
    Circulation. (2018).
  • Allergy inhibitory receptor-1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages.
    Iizuka A, Segawa S, Kondo Y, Kaneko S, Yokosawa M, Furuyama K, Miki H, Tahara-Hanaoka S, Shibuya A, Tsuboi H, Goto D, Matsumoto I, Shibayama S, Sumida T.
    Int J Rheum Dis. 2018;21(12):2071-2078.
  • *Exploring the Gut Fungi-Lung Allergy Axis.
    Shibuya A & Shibuya K.
    Cell Host Microb. 2018;24(6):755-757.
  • Elovl6 regulates mechanical damage–induced keratinocyte death and skin inflammation.
    Nakamura Y, Matsuzaka T, Tahara-Hanaoka S, Shibuya K, Shimano H, Nakahashi-Oda C, Shibuya A.
    Cell Death and Diseases. 2018;9(12):1181.
  • Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain.
    Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Muratani M, Shibuya A, Nabeshima YI, Yanagisawa M, Funato H, Hoshino M.
    Cell Rep. 2018;24(1):79-94.
  • Glycoprotein nmb is exposed on the surface of dormant breast cancer cells and induces stem cell-like properties.
    Chen C, Okita Y, Watanabe Y, Abe F, Fikry MA, Ichikawa Y, Suzuki H, Shibuya A, Kato M.
    Cancer Res. 2018;78(22):6424-6435.
  • Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation.
    Takenaka E., Vo A., Yamashita-Kanemaru Y., Shibuya A, Shibuya K.
    Scientific Reports. 2018;8(1):15180.
  • Cutting Edge: Identification of Marginal Reticular Cells as Phagocytes of Apoptotic B Cells in Germinal Centers.
    Sato K, Honda SI, Shibuya A, Shibuya K.
    J Immunol. 2018;200(11):3691-3696.
  • TX99 Is a Neutralizing Monoclonal Antibody Against Mouse TIGIT.
    Nakamura Y, Naito K, Yamashita-Kanemaru Y, Komori D, Hirochika R, Shibuya A, Shibuya K.
    Monoclon Antib Immunodiagn Immunother. 2018;37(2):105-109.
  • Circulating concentrations of insulin resistance-associated hepatokines, selenoprotein P and leukocyte cell-derived chemotaxin 2, during an oral glucose tolerance test in humans.
    Mohri K, Misu H, Takayama H, Ishii KA, Kikuchi A, Lan F, Enyama Y, Takeshita Y, Saito Y, Kaneko S, Takamura T.
    Biol Pharm Bull. 2018 Dec 28. doi: 10.1248/bpb.b18-00549.
  • Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.
    Oo SM, Misu H, Saito Y, Tanaka M, Kato S, Kita Y, Takayama H, Takeshita Y, Kanamori T, Nagano T, Nakagen M, Urabe T, Matsuyama N, Kaneko S, Takamura T.
    Sci Rep. 8(1):16727 2018
  • Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits.
    Saito Y, Misu H, Takayama H, Takashima SI, Usui S, Takamura M, Kaneko S, Takamura T, Noguchi N.
    Biol Pharm Bull. 41(5):828-832 2018
  • Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples.
    Sugiyama M, Kikuchi A, Misu H, Igawa H, Ashihara M, Kushima Y, Honda K, Suzuki Y, Kawabe Y, Kaneko S, Takamura T.
    PLoS One. 13(3):e0194798 2018
  • Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice.
    Chadani H, Usui S, Inoue O, Kusayama T, Takashima SI, Kato T, Murai H, Furusho H, Nomura A, Misu H, Takamura T, Kaneko S, Takamura M.
    Int J Mol Sci. 19(3). pii: E878 2018
  • Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease.
    Yamada K, Mizukoshi E, Seike T, Horii R, Kitahara M, Sunagozaka H, Arai K, Yamashita T, Honda M, Kaneko S.
    PLoS One. 13(1):e0191026 2018
  • Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.
    Watanabe H, Inaba Y, Kimura K, Matsumoto M, Kaneko S, Kasuga M, Inoue H.
    Nat Commun. 9(1):30 2018.
  • *Asymmetric integration of single-cell transcriptomic data using latent Dirichlet allocation and Procrustes analysis
    Eto M, Hirota W, Seno S, Matsuda H.
    IEEE International Conference on Bioinformatics and Biomedicine, 2129-2135, 2018.
  • Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism.
    Nagahama Y, Shimoda M, Mao G, Singh SK, Kozakai Y, Sun X, Motooka D, Nakamura S, Tanaka H, Satoh T, Maeda K, Akira S.
    Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11036-11041.
  • Infection with flaviviruses requires BCLXL for cell survival.
    Suzuki T, Okamoto T, Katoh H, Sugiyama Y, Kusakabe S, Tokunaga M, Hirano J, Miyata Y, Fukuhara T, Ikawa M, Satoh T, Yoshio S, Suzuki R, Saijo M, Huang DCS, Kanto T, Akira S, Matsuura Y.
    PLoS Pathog. 2018 Sep 27;14(9):e1007299. doi: 10.1371/journal.ppat.1007299. eCollection 2018 Sep.
  • Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
    Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman Strong C, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN.
    Nature. 2018 Apr;556(7702):501-504.
  • BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation.
    Kanemaru H, Yamane F, Tanaka H, Maeda K, Satoh T, Akira S.
    Int Immunol. 2018 May 24;30(6):255-265. doi: 10.1093/intimm/dxy023.
  • Production of low-molecular weight soluble yeast b-glucans by an acid degradation method.
    Ishimoto, Y., Ishibashi, K. I., Yamanaka, D., Adachi, Y., Kanzaki, K., Iwakura, Y., and Ohno, N.
    Int. J. Biol. Macromol., 107, 2269-2278 (2018).
  • Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2.
    Aono Y, Horinaka M, Iizumi Y, Watanabe M, Taniguchi T, Yasuda S, Sakai T.
    Biochem Biophys Res Commun. 2018 Nov 10;505(4):1203-1210.
  • *Mevalonate pathway blockage enhances the efficacy of mTOR inhibitors with the activation of retinoblastoma protein in renal cell carcinoma.
    Hagiwara N, Watanabe M, Iizuka-Ohashi M, Yokota I, Toriyama S, Sukeno M, Tomosugi M, Sowa Y, Hongo F, Mikami K, Soh J, Fujito A, Miyashita H, Morioka Y, Miki T, Ukimura O, Sakai T.
    Cancer Lett. 2018 Sep 1;431:182-189.
  • *Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells.
    Iizuka-Ohashi M, Watanabe M, Sukeno M, Morita M, Hoang NTH, Kuchimaru T, Kizaka-Kondoh S, Sowa Y, Sakaguchi K, Taguchi T, Sakai T.
    Oncotarget. 2018 Apr 13;9(28):19597-19612.
  • Reinforce the antitumor activity of CD8+ T cells via glutamine restriction.
    abe S, Yamada T, Suzuki J, Toriyama K, Yasuoka T, Kuwahara M, Shiraishi A, Takenaka K, Yasukawa M, Yamashita M.
    Cancer Sci. 109: 3737-3750, doi: 10.1111/cas.13827. 2018
  • The tumor suppressor menin prevents effector CD8 T cell dysfunction by targeting mTORC1-dependent metabolic activation.
    Suzuki J, Yamada T, Inoue K, Nabe S, Kuwahara M, Takemori N, Takemori A, Matsuda D, Kanoh M, Imai Y, Yasukawa M, Yamashita M.
    Nat. Commun. 9: 3296, doi: 10.1038/s41467-018-05854-6. 2018.
  • Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells.
    Miyai T, Takano J, Endo TA, Kawakami E, Agata Y, Motomura Y, Kubo M, Kashima Y, Suzuki Y, Kawamoto H, Ikawa T.
    Genes Dev. 32(2):112-126, 2018
  • GITR cosignal in ILC2s controls allergic lung inflammation.
    Nagashima H, Okuyama Y, Fujita T, Takeda T, Motomura Y, Moro K, Hidaka T, Omori K, Sakurai T, Machiyama T, Ndhlovu LC, Riccardi C, So T, Ishii N.
    J Allergy Clin Immunol. 141(5):1939-1943, 2018
  • Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy.
    Kuzuya K, Ichihara S*, Suzuki Y, Inoue C, Ichihara G, Kurimoto S, Oikawa S.
    PLoS One. 2018 Feb 13;13(2):e0192624.
  • The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes.
    Matsushita J, Okamura K, Nakabayashi K, Suzuki T, Horibe Y, Kawai T, Sakurai T, Yamashita S, Higami Y, Ichihara G, Hata K, Nohara K*.
    BMC CANCER 2018; 317.
  • Pulmonary hypofunction due to calcium carbonate nanomaterial exposure in occupational workers: a cross-sectional study.
    Li G, Liang L, Yang J, Zeng L, Xie Z, Zhong Y, Ruan X, Dong M, Yang Z, Lai G, Huang W, Yang A, Chen J, Wu B, Xu H, Meng D, Hu S, Xia L, Yang X, Li L, Ichihara S, Ichihara G, Huang H, Huang Z*.
    Nanotoxicology 2018; 571-585.
  • *Exposure to 1,2-dichloropropane upregulates the expression of activation-induced cytidine deaminase (AID) in human cholangiocytes co-cultured with macrophages.
    Zong C, Kimura Y, Kinoshita K, Takasu S, Zhang X, Sakurai T, Sekido Y, Ichihara S, Endo G, Ichihara G*.
    Toxicological Sciences 2018 Nov 19. doi: 10.1093/toxsci/kfy280.
  • Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3-epoxypropyl methacrylate, and classifications on carcinogenicity.
    Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health, Araki A, Azuma K, Endo G, Endo Y, Fukushima T, Hara K, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara G, Ikeda M, Ishitake T, Ito A, Ito Y, Iwasawa S, Kakumu T, Kamijima M, Karita K, Katoh T, Kawai T, Kawamoto T, Kumagai S, Kusaka Y, Matsumoto A, Miyagawa M, Miyauchi H, Morimoto Y, Nagano K, Naito H, Nakajima T, Nakano M, Nomiyama T, Okuda H, Okuda M, Omae K, Sakurai H, Sato K, Sobue T, Suwazono Y, Takebayashi T, Takeshita T, Takeuchi A, Takeuchi A, Tanaka M, Tanaka S, Tsukahara T, Tsunoda M, Ueno S, Ueyama J, Umeda Y, Yamamoto K, Yamano Y, Yamauchi T, Yano E.
    Journal of Occupational Health 2018; 60: 333-335.
  • International Agency for Research on Cancer Monograph Working Group Carcinogenicity of isobutyl nitrite, β-picoline, and some acrylates.
    Kromhout H, Friesen M, Marques MM, Sergi CM, Abdallah M, Benke G, Cesta M, Germolec D, Houck K, Ichihara G, Jameson CW, Kanno J, Pogribny I, Svendsen C, Benbrahim-Tallaa L, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Hall A, Jaillet C, Mattock H, Straif K
    Lancet Oncol. 2018 Aug;19(8):1020-1022. doi: 10.1016/S1470-2045(18)30491-1.
  • *Familial episodic limb pain in kindreds with novel Nav1.9 mutations.
    Kabata R, Okuda H, Noguchi A, Kondo D, Fujiwara M, Hata K, Kato Y, Ishikawa K, Tanaka M, Sekine Y, Hishikawa N, Mizukami T, Ito J, Akasaka M, Sakurai K, Yoshida T, Minoura H, Hayashi T, Inoshita K, Matsuyama M, Kinjo N, Cao Y, Inoue S, Kobayashi H, Harada KH, Youssefian S, Takahashi T, Koizumi A.
    PLoS One. 2018 Dec 17;13(12):e0208516.
  • *Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice.
    Kobayashi H, Kabata R, Kinoshita H, Morimoto T, Ono K, Takeda M, Choi J, Okuda H, Liu W, Harada KH, Kimura T, Youssefian S, Koizumi A.
    Pulm Circ. 2018 Jul-Sep;8(3):2045894018778155.
  • *Dysregulation of RNF213 promotes cerebral hypoperfusion.
    Morimoto T, Enmi JI, Hattori Y, Iguchi S, Saito S, Harada KH, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A.
    Sci Rep. 2018 Feb 26;8(1):3607.
  • *β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.
    Choi J, Kobayashi H, Okuda H, Harada KH, Takeda M, Fujimoto H, Yamane S, Tanaka D, Youssefian S, Inagaki N, Koizumi A.
    PLoS One. 2018 Jan 5;13(1):e0190863.
  • Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes.
    Osawa T, Fujihara K, Harada M, Yamamoto M, Ishizawa M, Suzuki H, Ishiguro H, Matsubayashi Y, Seida H, Yamanaka N, Tanaka S, Shimano H, Kodama S, Sone H.
    Diabetes Metab Res Rev. 2018; Dec 22:e3120.
  • Protein Residue Networks from Energetic and Geometric Data: Are They Identical?
    Sladek V, Tokiwa H, Shimano H, Shigeta Y.
    J Chem Theory Comput. 2018 Nov 30.. [Epub ahead of print]
  • Network meta-analysis of the relative efficacy of bariatric surgeries for diabetes remission.
    Kodama S, Fujihara K, Horikawa C, Harada M, Ishiguro H, Kaneko M, Furukawa K, Matsubayashi Y, Matsunaga S, Shimano H, Tanaka S, Kato K, Sone H.
    Obes Rev. 2018 Dec;19(12):1621-1629.
  • Relationship between intake of fruit separately from vegetables and triglycerides – A meta-analysis.
    Kodama S, Horikawa C, Fujihara K, Ishii D, Hatta M, Takeda Y, Kitazawa M, Matsubayashi Y, Shimano H, Kato K, Tanaka S, Sone H.
    Clin Nutr ESPEN. 2018 Oct;27:53-58.
  • The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice.
    Araki M, Nakagawa Y, Oishi A, Han SI, Wang Y, Kumagai K, Ohno H, Mizunoe Y, Iwasaki H, Sekiya M, Matsuzaka T, Shimano H.
    Int J Mol Sci. 2018 Jul 23;19(7). pii: E2148.
  • Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes.
    Li N, Li M, Hong W, Shao J, Xu H, Shimano H, Lu J, Xu Y.
    Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2881-2889.
  • Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes.
    Furukawa S, Suzuki H, Fujihara K, Kobayashi K, Iwasaki H, Sugano Y, Yatoh S, Sekiya M, Yahagi N, Shimano H.
    Diabetes Res Clin Pract. 2018 Jul;141:237-243.
  • *CREBH Regulates Systemic Glucose and Lipid Metabolism.
    Nakagawa Y, Shimano H.
    Int J Mol Sci. 2018 May 8;19(5). pii: E1396. 
  • Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis.
    Ozawa Y, Tamura T, Owada Y, Shimizu Y, Kemmochi A, Hisakura K, Matsuzaka T, Shimano H, Isoda H, Ohkohchi N.
    World J Gastroenterol. 2018 Apr 21;24(15):1622-1631.
  • *Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance.
    Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H.
    Endocrinology. 2018 Jun 1;159(6):2308-2323.
  • *Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα.
    Yamamoto Y, Takei K, Arulmozhiraja S, Sladek V, Matsuo N, Han SI, Matsuzaka T, Sekiya M, Tokiwa T, Shoji M, Shigeta Y, Nakagawa Y, Tokiwa H, Shimano H.
    Biochem Biophys Res Commun. 2018 May 5;499(2):239-245.
  • Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.
    Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R, Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama N, Shimano H, Kasahara T, Takahashi M.
    Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):744-756.
  • Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood.
    Yuan X, Tsujimoto K, Hashimoto K, Kawahori K, Hanzawa N, Hamaguchi M, Seki T, Nawa M, Ehara T, Kitamura Y, Hatada I, Konishi M, Itoh N, Nakagawa Y, Shimano H, Takai-Igarashi T, Kamei Y, Ogawa Y.
    Nat Commun. 2018 Feb 12;9(1):636.
  • Age-dependent changes in dynamic standing-balance ability evaluated quantitatively using a stabilometer.
    Suzuki Y, Yatoh S, Suzuki H, Tanabe Y, Shimizu Y, Hada Y, Shimano H.
    J Phys Ther Sci. 2018 Jan;30(1):86-91.
  • A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes.
    Piao X, Yahagi N, Takeuchi Y, Aita Y, Murayama Y, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.
    FEBS Lett. 2018 Feb;592(3):422-433.
  • A Rare Coexistence of Pheochromocytoma and Parkinson’s Disease With Diagnostic Challenges.
    Matsumura-Matsuda E, Sekiya M, Omoto-Inuzuka M, Santo K, Shikama A, Kuba M, Sugano Y, Iwasaki H, Yatoh S, Sato T, Hara H, Takekoshi K, Suzuki H, Shimano H.
    Intern Med. 2018 Apr 1;57(7):979-985.
  • Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2.
    Morikawa SY, Fujihara K, Hatta M, Osawa T, Ishizawa M, Yamamoto M, Furukawa K, Ishiguro H, Matsunaga S, Ogawa Y, Shimano H, Sone H.
    Pediatr Diabetes. 2018 Jun;19(4):593-602.
  • Monopoiesis in humans and mice.
    Kawamura S, Ohteki T.
    Int Immunol 30: 503-5093. 2018
  • IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo.
    Nakanishi Y, Sato T, Takahashi K, Ohteki T.
    Mucosal Immunol 59: 812-818. 2018
  • Macrophages in inflammation, repair and regeneration.
    Oishi Y, Manabe I.
    Int Immunol 2018; 30(11):511-528.
  • *Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique.
    Aiba T, Saito T, Hayashi A, Sato S, Yunokawa H, Maruyama T, Fujibuchi W, Ohsako S*.
    Genes Environ. 2018 Jun 4;40:12.
  • *Detection of dioxin-induced demethylation of mouse Cyp1a1 gene promoter by a new labeling method for short DNA fragments possessing 5′-methylcytosine at the end.
    Kurita H, Aiba T, Saito T, Ohsako S*.
    Genes Environ. 2018 Jan 10;40:1.
  • Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter.
    Ohsako S*, Aiba T*, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K, Kojima Y.
    Arch Environ Contam Toxicol. 2018 Feb;74(2):240-247.
  • Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis.
    Souma K, Shichino S, Hashimoto S, Ueha S, Tsukui T, Nakajima T, Suzuki HI, Shand FHW, Inagaki Y, Nagase T, Matsushima K
    Scientific reports. 8(1) 16642 2018
  • Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation
    Kazushige Shiraishi, Shigeyuki Shichino, Satoshi Ueha, Takuya Nakajima, Shinichi Hashimoto, Satoshi Yamazaki, Kouji Matsushima
    iScience. Volume 11, 25 January 2019, Pages 318-333
  • STAM-binding protein regulates melanoma metastasis through SLUG stabilization.
    Iwakami Y, Yokoyama S, Watanabe K, Hayakawa Y.
    Biochem Biophys Res Commun. 2018;507(1-4):484-488.
  • Lung-resident natural killer cells control pulmonary tumor growth in mice.
    Yamamoto Y, Miyazato K, Takahashi K, Yoshimura N, Tahara H, Hayakawa Y
    Cancer Sci. 2018;109(9):2670-2676.
  • A Gata3 3′ distal otic vesicle enhancer directs inner ear-specific Gata3 expression. 
    Moriguchi T, Hoshino T, Rao A, Yu L, Takai J, Uemura S, Ise K, Nakamura Y, Lim KC, Shimizu R, Yamamoto M and Engel JD. 
    Mol Cell Biol. in press
  • Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer.
    Kishikawa T, Otsuka M, Suzuki T, Seimiya T, Sekiba K, Ishibashi R, Tanaka E, Ohno M, Yamagami M, Koike K.
    Mol Cancer Res in press. 

  • MicroRNA-7: A potent suppressor of the malignant potential of hepatocellular carcinoma.
    Otsuka M, Tanaka E, Sekiba K, Seimiya T, Yamagami M, Koike K. 
    Non-coding RNA Investig. in press.

  • HBV pathogenesis: Fresh insights into HBV RNA.
    Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K. 
    World J Gastroetenrol. in press.

  • DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels. 
    Sekiba K, Otsuka M, Ohno M, Kishikawa T, Yamagami M, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K.
    Oncotarget 2018; 9(39):20953-20964.

  • β-glucans in food modify colonic microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-dependent manner.
    Kamiya, T., Tang, C., Kadoki, M., Oshima, K., Hattori, M., Saijo, S., Adachi, Y., Ohno, N., and Iwakura, Y.
    Mucosal Immunol., 11, 763-773 (2018).

  • Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of intestinal microbiota.
    Tang, C., Kakuta, S., Shimizu, K., Kadoki, M., Kamiya, T., Shimazu, T., Kubo, S., Saijo, S., Ishigame, H., Nakae, S., and Iwakura, Y.
    Nature Immunol., 19, 755–765 (2018)

  • Effects of high fructose intake on liver injury progression in high fat diet induced fatty liver disease in ovariectomized female mice.
    T. Ohashi, M. Kato, A. Yamasaki, A. Kuwano, H. Suzuki, M. Kohjima, and Y. Ogawa. 
    Food Chem. Toxicol. 118: 190-197, 2018.

  • Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis.
    T. Goto, M. Itoh, T. Suganami, S. Kanai, I. Shirakawa, T. Sakai, M. Asakawa, T. Yoneyama, T. Kai, and Y. Ogawa.
    Sci. Rep. 8: e8157, 2018.

  • Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein.
    Yunoki K, Yoshinaga S, Takeda M, Nagano R, Tsuchiya Y, Sonoda A, Tsuji T, Hirakane M, Toda E, Terashima Y, Matsushima K, Terasawa H.
    Genes Cells. 2018;23(2):70-79.

  • Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T-cells mainly in the spleen.
    Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
    Int Immunol. 2018; 30(2):53-67.

  • Increased diversity with reduced “diversity evenness” of tumor infiltrating T-cells for the successful cancer immunotherapy.
    Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K.
    Sci Rep. 2018;8(1):1058.

  • Dysregulation of RNF213 promotes cerebral hypoperfusion. 
    Takaaki Morimoto, Jun-ichiro Enmi, Yorito Hattori, Satoshi Iguchi, Satoshi Saito, Kouji H. Harada, Hiroko Okuda, Yohei Mineharu, Yasushi Takagi, Shohab Youssefian, Hidehiro Iida, Susumu Miyamoto, Masafumi Ihara, Hatasu Kobayashi, Akio Koizumi
    Sci. Rep. 2018;8(1):3607.

  • NK cells control tumor-promoting function of neutrophils in mice.
    Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y.
    Cancer Immunol Res. 2018; 6(3):348-357.
  • Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter.
    Ohsako S, Aiba T, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K, Kojima Y.
    Arch Environ Contam Toxicol. 2018;74(2):240-247.

2017年

  • *Exposure of Mice to 1,2-Dichloropropane Induces CYP450-Dependent Proliferation and Apoptosis of Cholangiocytes
    Zhang X、Zong C、Zhang L、Garner E、Sugie S、Huang C、Wu W、Chang J、Sakurai T、Kato M、Ichihara S、Kumagai S、Ichihara G*,.
    Toxicological Sciences 2018; 162: 559-569.
  • The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion.
    Mojic M, Takeda K, Hayakawa Y.
    Int J Mol Sci. 2017;19(1). pii: E89.
  • Long-Lasting Graft-Derived Donor T Cells Contribute to the Pathogenesis of Chronic Graft-versus-Host Disease in Mice.
    Kosugi-Kanaya M, Ueha S, Abe J, Shichino S, Shand FHW, Morikawa T, Kurachi M, Shono Y, Sudo N, Yamashita A, Suenaga F, Yokoyama A, Yong W, Imamura M, Teshima T, Matsushima K.
    Front Immunol. 2017;8:1842.
  • The HIV co-receptor CCR5 regulates osteoclast function.
    Ji-Won Lee, Akiyoshi Hoshino, Kazuki Inoue, Takashi Saitou, Shunsuke Uehara6, Yasuhiro Kobayashi, Satoshi Ueha, Kouji Matsushima, Akira Yamaguchi, Yuuki Imai and Tadahiro Iimura,
    Nature communication. 2017;8(1):2226
  • SREBP-regulated lipid metabolism: convergent physiology – divergent pathophysiology.
    Shimano H., Sato R.
    Nat Rev Endocrinol. 2017;13(12):710-730.
  • The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells.
    Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S.
    Eur J Immunol. 2017; 47(12):2163-2174.
  • ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.
    Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H.
    Cell Death Differ.  2017; 24(12):2066-2076.
  • RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease.
    Matsuda Y, Mineharu Y, Kimura M, Takagi Y, Kobayashi H, Hitomi T, Harada KH, Uchihashi Y, Funaki T, Miyamoto S, Koizumi A.
    J Stroke Cerebrovasc Dis. 2017;26(8):1841-1847.
  • Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.
    Sawada Y, Izumida Y, Takeuchi Y, Aita Y, Wada N, Li E, Murayama Y, Piao X, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Kadowaki T, Shimano H, Yahagi N.
    Biochem Biophys Res Commun. 2017; 493(1):40-45.
  • Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity.
    Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H.
    Diabetes. 2017; 66(7): 1833-1846.
  • Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B.
    Nosaka T, Naito T, Hiramatsu K, Ohtani M, Nemoto T, Marusawa H, Ma N, Hiraku Y, Kawanishi S, Yamashita T, Kaneko S, Nakamoto Y.
    PLoS One. 2017;12(10):e0185442.
  • Ribosomal protein S3 regulates XIAP expression independently of the NF-kB pathway in breast cancer cells.
    Ono H, Iizumi Y, Goi W, Sowa Y, Taguchi T, Sakai T. 
    Oncol Rep. 2017; 38(5): 3205-3210.
  • Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis and Cisplatin Resistance of Lung Cancer Cells.
    Endo S, Xia S, Suyama M, Morikawa Y, Oguri H, Hu D, Ao Y, Takahara S, Horino Y, Hayakawa Y, Watanabe Y, Gouda H, Hara A, Kuwata K, Toyooka N, Matsunaga T, Ikari A.
    J Med Chem. 2017;60(20):8441-8455.
  • Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma.
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