研究成果
2021年
- Jun Takai, Takashi Shimada, Tadaho Nakamura, James Douglas Engel, Takashi Moriguchi,
Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance,
iScience, Volume 24, Issue 8, 2021, 102836, - Johmura Y (Co-corresponding authors), Yamanaka T, Omori S, Wang TW, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S, Yamaguchi K, Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama KI, Furukawa Y, Imoto S, Nakanishi M (Co-corresponding authors). Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders. Science. 2021 Jan 15;371(6526):265-270. doi: 10.1126/science.abb5916.
- Suzuki N, Johmura Y (Co-corresponding authors), Wang TW, Migita T, Wu W, Noguchi R, Yamaguchi K, Furukawa Y, Nakamura S, Miyoshi I, Yoshimori T, Ohta T (Co-corresponding authors), Nakanishi M (Co-corresponding authors). TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis. Autophagy. 2021 Mar 11:1-18. doi: 10.1080/15548627.2021.1897961.
- Han W, Tang C, Baba S, Hamada T, Shimazu T, Iwakura Y. Ovalbumin-Induced Airway Inflammation Is Ameliorated in Dectin-1-Deficient Mice, in Which Pulmonary Regulatory T Cells Are Expanded through Modification of Intestinal Commensal Bacteria. J Immunol. 2021 May 1;206(9):1991-2000. doi: 10.4049/jimmunol.2001337.
- Sugita J, Fujiu K, Nakayama Y, Matsubara T, Matsuda J, Oshima T, Liu Y, Maru Y, Hasumi E, Kojima T, Seno H, Asano K, Ishijima A, Tomii N, Yamazaki M, Kudo F, Sakuma I, Nagai R, Manabe I, Komuro I. Cardiac macrophages prevent sudden death during heart stress. Nat Commun. 2021 Mar 26;12(1):1910
doi:10.1038/s41467-021-22178-0. - Kanamori Y, Tanaka M, Itoh M, Ochi K, Ito A, Hidaka I, Sakaida I, Ogawa Y, Suganami T. Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH. iScience. 2021 Jan 5;24(2):102032. doi: 10.1016/j.isci.2020.102032.
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Habu T, Harada KH. UBC13 is an RNF213-associated E2 ubiquitin-conjugating enzyme, and Lysine 63-linked ubiquitination by the RNF213-UBC13 axis is responsible for angiogenic activity. FASEB Bioadv. 2021 Jan 20;3(4):243-258.
doi: 10.1096/fba.2019-00092. - Kobayashi H, Harada KH, Habu T, Nakamura Y, Kim J, Koizumi A. RNF213 as a Susceptibility Gene for Moyamoya Disease has Multifunctional Roles in Biological Processes. Kuroda S. (eds) Moyamoya Disease: Current Knowledge and Future Perspectives. 2021. 47-60. doi:10.1007/978-981-33-6404-2_4
- Ishikawa H, Mutoh M, Sato Y, Doyama H, Tajika M, Tanaka S, Horimatsu T, Takeuchi Y, Kashida H, Tashiro J, Ezoe Y, Nakajima T, Ikematsu H, Hori S, Suzuki S, Otani T, Takayama T, Ohda Y, Mure K, Wakabayashi K, Sakai T. Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double- blind, randomised, two-by-two factorial design trial. Lancet Gastroenterol Hepatol. 2021 Jun;6(6):474-481. doi: 10.1016/S2468-1253(21)00018-2.
- Hamoya T, Fujii G, Iizumi Y, Narita T, Komiya M, Matsuzawa Y, Miki K, Kondo T, Kishimoto S, Watanabe K, Wakabayashi K, Sakai T, Toshima J, Mutoh M. Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling. Carcinogenesis. 2021 Feb 11;42(1):148-158. doi: 10.1093/carcin/bgaa084.
- Taniguchi K, Kageyama S, Moyama C, Ando S, Ii H, Ashihara E, Horinaka M, Sakai T, Kubota S, Kawauchi A, Nakata S. γ-Glutamylcyclotransferase, a novel regulator of HIF-1α expression, triggers aerobic glycolysis. Cancer Gene Ther. 2021 Jan 5. doi: 10.1038/s41417-020-00287-0.
- Watanabe M, Yamada Y, Kurumida Y, Kameda T, Sukeno M, Iizuka-Ohashi M, Sowa Y, Iizumi Y, Takakura H, Miyamoto S, Sakai T, Mutoh M. Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2. Cancers (Basel). 2021 Feb 26;13(5):982. doi: 10.3390/cancers13050982.
- Fujiwara T, Miyazato K, Takahashi K, Hayakawa Y. Establishment of bioluminescent imaging model using murine T cell lymphoma susceptive to NK cell-dependent immune-surveillance. J Immunol Methods. 2021 Apr;491:112993.
doi:10.1016/j.jim.2021.112993. - Nakamura K, Sakai S, Tsuyama J, Nakamura A, Otani K, Kurabayashi K, Yogiashi Y, Masai H, Shichita T. Extracellular DJ-1 induces sterile inflammation in the ischemic brain. PLOS Biol. 2021 May 20;19(5):e3000939. doi: 10.1371/journal.pbio.3000939.
- Iwasaki T, Miyajima-Nakano Y, Fukazawa R, Lin MT, Matsushita S, Hagiuda E, Taguchi A, Dikanov S, Oishi Y, Gennis R. Escherichia coli amino acid auxotrophic expression host strains for investigating protein structure-function relationships. J Biochem. 2021 Apr 29;169(4):387-394. doi: 10.1093/jb/mvaa140.
- Sekiya T, Kagawa S, Masaki K, Fukunaga K, Yoshimura A, Takaki S. Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors. iScience. 2021 Feb 7;24(3):102166. doi:
10.1016/j.isci.2021.102166. - Iwata Y, Sakai N, Yoneda I, Senda Y, Sakai-Takemori Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Furuichi K, Matsushima K, Wada T. D-Serine inhibits the attachment and biofilm formation of methicillin-resistant Staphylococcus aureus. Biochem Biophys Res Commun. 2021 Jan 22;537:50-56. doi: 10.1016/j.bbrc.2020.12.078.
- Ekuban FA, Zong C, Takikawa M, Morikawa K, Sakurai T, Ichihara S, Itoh K, Yamamoto M, Ohsako S, Ichihara G. Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice. Toxicology. 2021 May 30;456:152785.
doi: 10.1016/j.tox.2021.152785. - Nakagawa Y, Wang Y, Han SI, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano H. Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition. Cell Mol Gastroenterol Hepatol. 2021;11(4):949-971. doi: 10.1016/j.jcmgh.2020.11.004.
- Takata N, Ishii KA, Takayama H, Nagashimada M, Kamoshita K, Tanaka T, Kikuchi A, Takeshita Y, Matsumoto Y, Ota T, Yamamoto Y, Yamagoe S, Seki A, Sakai Y, Kaneko S, Takamura T. LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH. Sci Rep. 2021 Jan 12;11(1):555. doi: 10.1038/s41598-020-80689-0.
- Aoki H, Ueha S, Shichino S, Ogiwara H, Shitara K, Shimomura M, Suzuki T, Nakatsura T, Yamashita M, Kitano S, Kuroda S, Wakabayashi M, Kurachi M, Ito S, Doi T, Matsushima K. Transient Depletion of CD4+ Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer. Cancer Immunol Res. 2021 Mar 5.
doi: 10.1158/2326-6066.CIR-20-0989. - Murayama K, Matsuda H. Detecting Lineage-Specific Marker Genes for Tumor Evolution Based on Single Cell Transcriptome. International Journal of Bioscience, Biochemistry and Bioinformatics. 2021 doi: 10.17706/ijbbb.2021.11.3.50-57.
- Pauty J, Nakano S, Usuba R, Nakajima T, Johmura Y, Omori S, Sakamoto N, Kikuchi A, Nakanishi M, Matsunaga YT. A 3D tissue model-on-a-chip for studying the effects of human senescent fibroblasts on blood vessels. Biomater Sci. 2021 Jan 5;9(1):199-211. doi: 10.1039/d0bm01297a.
- Yamaguchi K, Kanno E, Tanno H, Sasaki A, Kitai Y, Miura T, Takagi N, Shoji M, Kasamatsu J, Sato K, Sato Y, Niiyama M, Goto Y, Ishii K, Imai Y, Saijo S, Iwakura Y, Tachi M, Kawakami K. Distinct Roles for Dectin-1 and Dectin-2 in Skin Wound Healing and Neutrophilic Inflammatory Responses. J Invest Dermatol. 2021 Jan 141(1):164-176.e8. doi: 10.1016/j.jid.2020.04.030.
- Abu Tayeh A, Funabiki M, Shimizu S, Satoh S, Sumin L, Iwakura Y, Kato H, Fujita T. Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton-Merten syndrome variant. Int Immunol. 2021 Mar 31;33(4):211-224.
doi: 10.1093/intimm/dxaa071. - Yabe R, Chung SH, Murayama MA, Kubo S, Shimizu K, Akahori Y, Maruhashi T, Seno A, Kaifu T, Saijo S, Iwakura Y. TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens. Nat Commun. 2021 Jan 4;12(1):94. doi: 10.1038/s41467-020-20307-9.
- Nakatsuka A, Yamaguchi S, Eguchi J, Kakuta S, Iwakura Y, Sugiyama H, Wada J. A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease. Commun Biol. 2021 Mar 19;4(1):373.
doi: 10.1038/s42003-021-01902-y. - Tun X, Hatano S, Mine K, Noguchi N, Iwakura Y, Sun X, Yoshikai Y. Vγ6+ γδ T cells are critical for protection against infection by Escherichia coli in mice. Eur J Immunol. 2021 Apr 1. doi: 10.1002/eji.202049010.
- Yamamoto H, Tomiyama C, Sato K, Kasamatsu J, Takano K, Umeki A, Nakahata N, Miyasaka T, Kanno E, Tanno H, Yamasaki S, Saijo S, Iwakura Y, Ishii K, Kawakami K. Dectin-2-mediated initiation of immune responses caused by influenza virus hemagglutinin. Biomed Res. 2021;42(2):53-66. doi: 10.2220/biomedres.42.53.
- Lin X, Twelkmeyer T, Zhu D, Zhang L, Zhao Y, Zhang C, Iwakura Y, Meng G, Hua Z, Yan B, Liu WJ, Luo Z, Gong S, Chen H, Li S, Hou B, Tang H. Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2019798118. doi: 10.1073/pnas.2019798118.
- Ito Y, Sasaki T, Li Y, Tanoue T, Sugiura Y, Skelly AN, Suda W, Kawashima Y, Okahashi N, Watanabe E, Horikawa H, Shiohama A, Kurokawa R, Kawakami E, Iseki H, Kawasaki H, Iwakura Y, Shiota A, Yu L, Hisatsune J, Koseki H, Sugai M, Arita M, Ohara O, Matsui T, Suematsu M, Hattori M, Atarashi K, Amagai M, Honda K. Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation. Cell Rep. 2021 Apr 27;35(4):109052. doi: 10.1016/j.celrep.2021.109052.
- Kuwabara Y, Ono S, Katayama A, Kurihara S, Oishi Y, Takeshita T. Plasma and follicular fluid osteopontin levels during ovarian cycle and their correlation with follicular fluid vascular endothelial growth factor levels. Sci Rep. 2021 Jan 11;11(1):286. doi: 10.1038/s41598-020-79453-1.
- Hashiuchi E, Watanabe H, Kimura K, Matsumoto M, Inoue H, Inaba Y. Diet Intake Control Is Indispensable for the Gluconeogenic Response to Sodium-Glucose Cotransporter 2 Inhibition in Male Mice. J Diabetes Investig. 2021 Jan;12(1):35-47. doi: 10.1111/jdi.13319.
- Egami R, Kokaji T, Hatano A, Yugi K, Eto M, Morita K, Ohno S, Fujii M, Hironaka KI, Uematsu S, Terakawa A, Bai Y, Pan Y, Tsuchiya T, Ozaki H, Inoue H, Uda S, Kubota H, Suzuki Y, Matsumoto M, Nakayama KI, Hirayama A, Soga T, Kuroda S. Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle. iScience. 2021 Feb 20;24(3):102217. doi: 10.1016/j.isci.2021.102217.
- Khoshkam Z, Aftabi Y, Stenvinkel P, Paige Lawrence B, Rezaei MH, Ichihara G, Fereidouni S. Recovery scenario and immunity in COVID-19 disease: A new strategy to predict the potential of reinfection. J Adv Res. 2021 Jul;31:49-60. doi: 10.1016/j.jare.2020.12.013.
- Masyita A, Salim E, Asri RM, Nainu F, Hori A, Yulianty R, Hatta M, Rifai Y, Kuraishi T. Molecular modeling and phenoloxidase inhibitory activity of arbutin and arbutin undecylenic acid ester. Biochem Biophys Res Commun. 2021 Apr 2;547:75-81. doi: 10.1016/j.bbrc.2021.02.006.
- Osawa T, Fujihara K, Harada Yamada M, Yamamoto M, Kitazawa M, Matsubayashi Y, Iwanaga M, Yamada T, Seida H, Kodama S, Nakagawa Y, Shimano H, Sone H. Severity of hypertension as a predictor of initiation of dialysis among study participants with and without diabetes mellitus. J Investig Med. 2021 Mar;69(3):724-729. doi: 10.1136/jim-2020-001489.
- Shimizu Y, Tamura T, Kemmochi A, Owada Y, Ozawa Y, Hisakura K, Matsuzaka T, Shimano H, Nakano N, Sakashita S, Oda T, Ohkohchi N. Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model. J Gastroenterol Hepatol. 2021 Mar;36(3):800-810. doi: 10.1111/jgh.15239.
- Isobe Y, Asakura H, Tsujiguchi H, Kannon T, Takayama H, Takeshita Y, Ishii KA, Kanamori T, Hara A, Yamashita T, Tajima A, Kaneko S, Nakamura H, Takamura T. Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans. Front Nutr. 2021 Feb 22;8:633703. doi: 10.3389/fnut.2021.633703.
- Yamashita T, Koshikawa N, Shimakami T, Terashima T, Nakagawa M, Nio K, Horii R, Iida N, Kawaguchi K, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kitao A, Kobayashi S, Takahara S, Imai Y, Yoshimura K, Murayama T, Nakamoto Y, Yoshida E, Yoshimura T, Seiki M, Kaneko S. Serum Laminin γ2 Monomer as a Diagnostic and Predictive Biomarker for Hepatocellular Carcinoma. Hepatology. 2021 Feb
doi: 10.1002/hep.31758. - Okanoue T, Shima T, Mitsumoto Y, Umemura A, Yamaguchi K, Itoh Y, Yoneda M, Nakajima A, Mizukoshi E, Kaneko S, Harada K. Artificial intelligence/neural network system for the screening of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Hepatology Research. 2021 Feb;51(5):554-569.
doi: 10.1111/hepr.13628. - Hashimoto S, Shirasaki T, Yamashita T, Iwabuchi S, Suzuki Y, Takamura Y, Ukita Y, Deshimaru S, Okayama T, Ikeo K, Kuroki K, Kawaguchi K, Mizukoshi E, Matsushima K, Honda M, Kaneko S. DOCK11 and DENND2A play pivotal roles in the maintenance of hepatitis B virus in host cells. PLoS One. 2021 Feb 4;16(2):e0246313.
doi: 10.1371/journal.pone.0246313. - Matsuki M, Inoue R, Murai A, Kubo T, Hashimoto S, Murata K, Kanaseki T, Tsukahara T, Nishida S, Tanaka T, Kitamura H, Masumori N, Hirohashi Y, Torigoe T. Neuregulin-1-β1 and γ-secretase play a critical role in sphere-formation and cell survival of urothelial carcinoma cancer stem-like cells. Biochem Biophys Res Commun. 2021 May 7;552:128-135. doi: 10.1016/j.bbrc.2021.03.038.
- Takeichi Y, Miyazawa T, Sakamoto S, Hanada Y, Wang L, Gotoh K, Uchida K, Katsuhara S, Sakamoto R, Ishihara T, Masuda K, Ishihara N, Nomura M, Ogawa Y. Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. Diabetologia. 2021 May 29.
doi: 10.1007/s00125-021-05488-2. - Kitabatake M, Matsumura Y, Ouji-Sageshima N, Nishioka T, Hara A, Kayano SI, Ito T. Persimmon-derived tannin ameliorates the pathogenesis of ulcerative colitis in a murine model through inhibition of the inflammatory response and alteration of microbiota. Sci Rep. 2021 Mar 31;11(1):7286. doi: 10.1038/s41598-021-86608-1.
2020年
- Omori S, Wang TW, Johmura Y (Co-corresponding authors), Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, Sakamoto T, Yamaguchi K, Hatakeyama S, Shimizu E, Katayama K, Yamada Y, Yamazaki S, Iwasaki K, Miyoshi C, Funato H, Yanagisawa M, Ueno H, Imoto S, Furukawa Y, Yoshida N, Matsushima K, Ueda HR, Miyajima A, Nakanishi M (Co-corresponding authors). Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo. Cell Metab. 2020 Nov 3;32(5):814-828.e6. doi: 10.1016/j.cmet.2020.09.006. Epub 2020 Sep 18.
- Nakayama Y, Fujiu K, Yuki R, Oishi Y, Morioka MS, Isagawa T, Matsuda J, Oshima T, Matsubara T, Sugita J, Kudo F, Kaneda A, Endo Y, Nakayama T, Nagai R, Komuro I, Manabe I. A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14365-14375. doi: 10.1073/pnas.2005924117.
- Oishi Y, Manabe I. Organ System Crosstalk in Cardiometabolic Disease in the Age of Multimorbidity. Front Cardiovasc Med. 2020 Apr 28; 7: 64.
doi: 10.3389/fcvm.2020.00064. - Panina Y, Karagiannis P, Kurtz A, Stacey GN, Fujibuchi W. Human Cell Atlas and cell-type authentication for regenerative medicine. Exp Mol Med. 2020 Sep;52(9):1443-1451. doi: 10.1038/s12276-020-0421-1.
- Tanaka M, Saka-Tanaka M, Ochi K, Fujieda K, Sugiura Y, Miyamoto T, Kohda H, Ito A, Miyazawa T, Matsumoto A, Aoe S, Miyamoto Y, Tsuboi N, Maruyama S, Suematsu M, Yamasaki S, Ogawa Y, Suganami T. C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury. J Exp Med. 2020 Nov 2;217(11):e20192230. doi: 10.1084/jem.20192230.
- Boku S, Watanabe M, Sukeno M, Yaoi T, Hirota K, Iizuka-Ohashi M, Itoh K, Sakai T. Deactivation of Glutaminolysis Sensitizes PIK3CA-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition. Cancers (Basel). 2020 Apr 30;12(5):1097. doi: 10.3390/cancers12051097.
- Sugimoto Y, Katsumi Y, Iehara T, Kaneda D, Tomoyasu C, Ouchi K, Yoshida H, Miyachi M, Yagyu S, Kikuchi K, Tsuchiya K, Kuwahara Y, Sakai T, Hosoi H. The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA. Mol Cancer Ther. 2020 Oct;19(10):1992-2000. doi: 10.1158/1535-7163.MCT-20-0243.
- Umemura S, Sowa Y, Iizumi Y, Kitawaki J, Sakai T. Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS-mutated ovarian cancer cells with high AXL expression. Cancer Sci. 2020 Jun;111(6):2052-2061. doi: 10.1111/cas.14414.
- Mutoh M, Yoshimura K, Fujii G, Nakamura T, Takeshita T, Wakabayashi K, Sakai T, Ishikawa H. Very Long-Term Treatment with a Lactobacillus Probiotic Preparation, Lactobacillus casei Strain Shirota, Suppresses Weight Loss in the Elderly. Nutrients. 2020 May 29;12(6):1599. doi: 10.3390/nu12061599.
- Ucche S, Murwanti R, Ritmaleni, Hayakawa Y. Anti-Metastatic Effects of Curcumin Analogues in a Mouse Breast Cancer Model. BPB Reports. 2020 3(2):76-79 doi;10.1248/bpbreports.3.2_76.
- Miyazato K, Hayakawa Y. Pharmacological targeting of natural killer cells for cancer immunotherapy. Cancer Sci. 2020 Jun;111(6):1869-1875. doi;10.1111/cas.14418.
- Miyazato K, Tahara H, Hayakawa Y. Antimetastatic effects of thalidomide by inducing the functional maturation of peripheral natural killer cells. Cancer Sci. 2020 Aug;111(8):2770-2778. doi: 10.1111/cas.14538.
- Hardianti B, Umeyama L, Li F, Yokoyama S, Hayakawa Y. Anti‑inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391. doi: 10.3892/mmr.2020.11615.
- Lin Umeyama, Shiori Kasahara, Misa Sugawara, Satoru Yokoyama, Ikuo Saiki, Yoshihiro Hayakawa. Anti-inflammatory effect of fermented brown rice and rice bran with Aspergillus oryzae on mice. Traditional & Kampo Medicine. 2020 Dec;doi: 10.1002/tkm2.1270.
- Susmitha GD, Miyazato K, Ogura K, Yokoyama S, Hayakawa Y. Anti-metastatic Effects of Baicalein by Targeting STAT3 Activity in Breast Cancer Cells. Biol Pharm Bull. 2020;43(12):1899-1905. doi: 10.1248/bpb.b20-00571.
- Sato T, Sase M, Ishikawa S, Kajita M, Asano J, Sato T, Mori Y, Ohteki T. Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine. Sci Rep. 2020 May 22;10(1):8308.
doi: 10.1038/s41598-020-64987-1. - Sekiya T, Kagawa S, Masaki K, Fukunaga K, Yoshimura A, Takaki S. Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors. iScience. 2021 Feb 7;24(3):102166. doi: 10.1016/j.isci.2021.102166.
- Matsue M, Ogura K, Sugiyama H, Miyoshi-Akiyama T, Takemori-Sakai Y, Iwata Y, Wada T, Okamoto S. Pathogenicity Characterization of Prevalent-Type Streptococcus dysgalactiae subsp. equisimilis Strains. Front Microbiol. 2020 Feb 4;11:97. doi: 10.3389/fmicb.2020.00097.
- Iwata Y, Sakai N, Yoneda I, Satou K, Furuichi K, Senda Y, Sakai-Takemori Y, Wada T, Fujita S, Ogura H, Sato K, Minami T, Yamaguchi K, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Sakai Y, Ikeo K, Shichino S, Ueha S, Nakajima T, Matsushima K, Wada T. The increased frequency of methicillin-resistant Staphylococcus aureus with low MIC of beta-lactam antibiotics isolated from hospitalized patients. J Infect Chemother. 2020 Jun;26(6):604-610. doi: 10.1016/j.jiac.2020.01.016.
- Zhang X, Morikawa K, Mori Y, Zong C, Zhang L, Garner E, Huang C, Wu W, Chang J, Nagashima D, Sakurai T, Ichihara S, Oikawa S, Ichihara G. Proteomic analysis of liver proteins of mice exposed to 1,2-dichloropropane. Arch Toxicol. 2020 Aug;94(8):2691-2705. doi: 10.1007/s00204-020-02785-4.
- Satoh A, Han SI, Araki M, Nakagawa Y, Ohno H, Mizunoe Y, Kumagai K, Murayama Y, Osaki Y, Iwasaki H, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Sone H, Shimano H. CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms. iScience. 2020 Mar 27;23(3):100930. doi: 10.1016/j.isci.2020.100930.
- Matsuzaka T, Kuba M, Koyasu S, Yamamoto Y, Motomura K, Arulmozhiraja S, Ohno H, Sharma R, Shimura T, Okajima Y, Han SI, Aita Y, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H. Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice. Hepatology. 2020 May;71(5):1609-1625. doi: 10.1002/hep.30953.
- Iwata Y, Satou K, Furuichi K, Yoneda I, Matsumura T, Yutani M, Fujinaga Y, Hase A, Morita H, Ohta T, Senda Y, Sakai-Takemori Y, Wada T, Fujita S, Miyake T, Yasuda H, Sakai N, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Miyagawa T, Hara A, Shimizu M, Kamikawa Y, Ikeo K, Shichino S, Ueha S, Nakajima T, Matsushima K, Kaneko S, Wada T. Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus. Int J Infect Dis. 2020 Feb;91:22-31. doi: 10.1016/j.ijid.2019.11.003.
- Fujimoto K, Seno S, Shigeta H, Mashita T, Ishii M, Matsuda H. Tracking and Analysis of FUCCI-Labeled Cells Based on Particle Filters and Time-to-Event Analysis. International Journal of Bioscience. Biochemistry and Bioinformatics. 2020 Jan doi: 10.17706/ijbbb.2020.10.2. 94-109.
- Yagi Y, Kuwahara M, Suzuki J, Imai Y, Yamashita M. Glycolysis and subsequent mevalonate biosynthesis play an important role in Th2 cell differentiation. Biochem Biophys Res Commun. 2020 Sep 17;530(2):355-361. doi: 10.1016/j.bbrc.2020.08.009.
- Toriyama K, Kuwahara M, Kondoh H, Mikawa T, Takemori N, Konishi A, Yorozuya T, Yamada T, Soga T, Shiraishi A, Yamashita M. T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Commun Biol. 2020 Jul 24;3(1):394. doi: 10.1038/s42003-020-01122-w.
- Ito H, Asano Y. Composition Proposal Generation for Manga Creation Support. IEICE Trans. Inf. Syst. 2020 May E103.D(5): 949-957. doi: 10.1587/transinf.2019DAP0005.
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- Itoh M, Ogawa Y, Suganami T. Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis: role of macrophages and fibroblasts in the liver. Nagoya J Med Sci. 2020 Aug;82(3):391-397. doi: 10.18999/nagjms.82.3.391.
- Yoshida T, Tsuchiya A, Kumagai M, Takeuchi S, Nojiri S, Watanabe T, Ogawa M, Itoh M, Takamura M, Suganami T, Ogawa Y, Terai S. Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH. Biochem Biophys Res Commun. 2020 Oct 1;530(4):665-672.
doi: 10.1016/j.bbrc.2020.07.099. - Fu Y, Kaneko K, Lin HY, Mo Q, Xu Y, Suganami T, Ravn P, Fukuda M. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. 2020 Sep 1;161(9):bqaa102. doi: 10.1210/endocr/bqaa102.
- Watanabe T, Tsuchiya A, Takeuchi S, Nojiri S, Yoshida T, Ogawa M, Itoh M, Takamura M, Suganami T, Ogawa Y, Terai S. Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles. Regen Ther. 2020 May 15;14:252-261. doi: 10.1016/j.reth.2020.03.012.
- Kitazawa M, Hayashi S, Imamura M, Oishi Y, Takeda S, Kaneko-Ishino T, and Ishino F. Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to the Temple and Kagami-Ogata syndromes. Development. 2020 Sep 2;147(21):dev185918. doi: 10.1242/dev.185918.
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- Kanno A, Asahara SI, Furubayashi A, Masuda K, Yoshitomi R, Suzuki E, Takai T, Kimura-Koyanagi M, Matsuda T, Bartolome A, Hirota Y, Yokoi N, Inaba Y, Inoue H, Matsumoto M, Inoue K, Abe T, Wei FY, Tomizawa K, Ogawa W, Seino S, Kasuga M, Kido Y. GCN2 regulates pancreatic β-cell mass by sensing intracellular amino acid levels. JCI Insight. 2020 May 7;5(9) :e128820. doi: 10.1172/jci.insight.128820.
- Matsumoto A, Kuwata H, Kimura S, Matsumoto H, Ochi K, Moro-Oka Y, Watanabe A, Yamada H, Ishii H, Miyazawa T, Chen S, Baba T, Yoshida H, Nakamura T, Inoue H, Ogawa Y, Tanaka M, Miyahara Y, Suganami T. Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system. Commun Biol. 2020 Jun 17;3(1):313. doi: 10.1038/s42003-020-1026-x.
- Kokaji T, Hatano A, Ito Y, Yugi K, Eto M, Ohno S, Fujii M, Hironaka K, Egami R, Inoue H, Uda S, Kubota H, Suzuki Y, Ikeda K, Arita M, Matsumoto M, Nakayama KI, Ohishi M, Ueno A, Endo K, Hirayama A, Soga T, Kuroda K. Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity Sci Signal 2020 Dec 1;13(660):eaaz1236. doi: 10.1126/scisignal.aaz1236.
- Tsukada K, Shinki S, Kaneko A, Murakami K, Irie K, Murai M, Miyoshi H, Dan S, Kawaji K, Hayashi H, Kodama EN, Hori A, Salim E, Kuraishi T, Hirata N, Kanda Y, Asai T. Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones. Nat Commun. 2020 Apr 14;11(1):1830. doi: 10.1038/s41467-020-15664-4.
- Nainu F, M. Djide N, Subehan, Sartini, Salim E, Kuraishi T. Protective signatures of roselle (Hibiscus sabdariffa L.) Calyx Fractions against Staphylococcus aureus in Drosophila Infection Model. HAYATI J Biosci. 2020 Oct doi: 10.4308/hjb.27.4.306.
- Yoshinari Y, Ameku T, Kondo S, Tanimoto H, Kuraishi T, Shimada-Niwa Y, Niwa R. Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster. Elife. 2020 Oct 20;9:e57101.
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- Matsushita J, Suzuki T, Okamura K, Ichihara G, Nohara K. Identification by TCGA database search of five genes that are aberrantly expressed and involved in hepatocellular carcinoma potentially via DNA methylation changes. Environ Health Prev Med. 2020 Jul 23;25(1):31. doi: 10.1186/s12199-020-00871-8.
- Aftabi Y, Khoshkam Z, Amiri-Sadeghan A, Khalili Y, Ichihara G. An introduction to EpiPol (Epigenetic affecting Polymorphism) concept with an in silico identification of CpG-affecting SNPs in the upstream regulatory sequences of human AHR gene. Meta Gene. 2020 Dec. Vol.26. doi: 10.1016/j.mgene.2020.100805.
- Mizunoe Y, Kobayashi M, Hoshino S, Tagawa R, Itagawa R, Hoshino A, Okita N, Sudo Y, Nakagawa Y, Shimano H, Higami Y. Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes. Sci Rep. 2020 Jan 20;10(1):634. doi: 10.1038/s41598-020-57428-6.
- Ma Y, Sekiya M, Kainoh K, Matsuda T, Iwasaki H, Osaki Y, Sugano Y, Suzuki H,Takeuchi Y, Miyamoto T, Yahagi N, Nakagawa Y, Matsuzaka T, Shimano H. Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1. Biochem Biophys Res Commun. 2020 Mar 5;523(2):354-360. doi: 10.1016/j.bbrc.2019.12.070.
- Sakai Y, Chen G, Ni Y, Zhuge F, Xu L, Nagata N, Kaneko S, Ota T, Nagashimada M. DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice. Endocrinology. 2020 Oct 1;161(10):bqaa139.
doi: 10.1210/endocr/bqaa139. - Sakai Y, Arie H, Ni Y, Zhuge F, Xu L, Chen G, Nagata N, Suzuki T, Kaneko S, Ota T, Nagashimada M. Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability. J Endocrinol. 2020 Nov;247(2):169-181.
doi: 10.1530/JOE-20-0105. - Zhang D, Iwabuchi S, Baba T, Hashimoto SI, Mukaida N, Sasaki SI. Involvement of a Transcription factor, Nfe2, in Breast Cancer Metastasis to Bone. Cancers (Basel). 2020 Oct 16;12(10):3003. doi: 10.3390/cancers12103003.
- Doshida Y, Sano H, Iwabuchi S, Aigaki T, Yoshida M, Hashimoto S, Ishigami A. Age-associated changes in the transcriptomes of non-cultured adipose-derived stem cells from young and old mice assessed via single-cell transcriptome analysis. PLoS One. 2020 Nov 25;15(11):e0242171. doi: 10.1371/journal.pone.0242171.
- Mizoguchi I, Ohashi M, Hasegawa H, Chiba Y, Orii N, Inoue S, Kawana C, Xu M, Sudo K, Fujita K, Kuroda M, Hashimoto SI, Matsushima K, Yoshimoto T. EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin. J Clin Invest. 2020 Nov 2;130(11):6124-6140. doi: 10.1172/JCI122732.
- Matsuki M, Inoue R, Murai A, Kubo T, Hashimoto S, Murata K, Kanaseki T, Tsukahara T, Nishida S, Tanaka T, Kitamura H, Masumori N, Hirohashi Y, Torigoe T. Neuregulin-1-β1 and γ-secretase play a critical role in sphere-formation and cell survival of urothelial carcinoma cancer stem-like cells. Biochem Biophys Res Commun. 2021 May 7;552:128-135. doi: 10.1016/j.bbrc.2021.03.038.
- Hashimoto S, Shirasaki T, Yamashita T, Iwabuchi S, Suzuki Y, Takamura Y, Ukita Y, Deshimaru S, Okayama T, Ikeo K, Kuroki K, Kawaguchi K, Mizukoshi E, Matsushima K, Honda M, Kaneko S. DOCK11 and DENND2A play pivotal roles in the maintenance of hepatitis B virus in host cells. PLoS One. 2021 Feb 4;16(2):e0246313.
doi: 10.1371/journal.pone.0246313. - Takemori A, Butcher DS, Harman VM, Brownridge P, Shima K, Higo D, Ishizaki J, Hasegawa H, Suzuki J, Yamashita M, Loo JA, Loo RRO, Beynon RJ, Anderson LC, Takemori N. PEPPI-MS: Polyacrylamide-Gel-Based Prefractionation for Analysis of Intact Proteoforms and Protein Complexes by Mass Spectrometry. J Proteome Res. 2020 Sep 4;19(9):3779-3791. doi: 10.1021/acs.jproteome.0c00303.
- Terada-Ikeda C, Kitabatake M, Hiraku A, Kato K, Yasui S, Imakita N, Ouji-Sageshima N, Iwabuchi N, Hamada K, Ito T. Maternal supplementation with Bifidobacterium breve M-16V prevents their offspring from allergic airway inflammation accelerated by the prenatal exposure to an air pollutant aerosol. PLoS One. 2020 Sep 11;15(9):e0238923. doi: 10.1371/journal.pone.
- Kawara A, Mizuta R, Fujisawa M, Ito T, Li C, Nakamura K, Sun C, Kuwabara M, Kitabatake M, Yoshimura T, Matsukawa A. Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin. Sci Rep. 2020 Oct 5;10(1):16490. doi: 10.1038/s41598-020-73752-3.
- Shibata T, Makino A, Ogata R, Nakamura S, Ito T, Nagata K, Terauchi Y, Oishi T, Fujieda M, Takahashi Y, Ato M. Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization. J Clin Invest. 2020 Jun 1;130(6):3021-3037. doi: 10.1172/JCI125505.
- Sawabata N, Nakamura T, Kawaguchi T, Watanabe T, Ouji NS, Ito T, Taniguchi S. Circulating tumor cells detected only after surgery for non-small cell lung cancer: is it a predictor of recurrence? J Thorac Dis. 2020 Sep;12(9):4623-4632.
doi: 10.21037/jtd-20-1636.
2019年
- Shigeta H, Seno S, Nishizawa S, Uchida Y, Kikuta J, Ishii M, Matsuda H. Analyzing leukocyte migration trajectories by deformable image matching. IEEE International Conference on Bioinformatics and Bioengineering, 94-98, 2019.
- Osato N, Shigeta H, Seno S, Uchida Y, Kikuta J, Ishii M, Matsuda H. Single-cell transcriptome analysis of mouse leukocytes in inflammatory stimulation. IEEE International Conference on Bioinformatics and Biomedicine, 1229-1231, 2019.
- Takai J, Ohtsu H, Sato A, Uemura S, Fujimura T, Yamamoto M, Moriguchi T, Lipopolysaccharide-induced expansion of histidine decarboxylase-expressing Ly6G+ myeloid cells identified by exploiting histidine decarboxylase BAC-GFP transgenic mice. Sci Rep. 2019;9(1):15603.
- Shiratori, K., Kanemaru, K., Ogura, T., Nakajima, A., Sugizaki, Y., Fukuyama, T., Iwakura, Y., Nakamura, Y., and Fukami, K. Epidermal loss of phospholipase Cδ1 attenuates irritant contact dermatitis. Biochem. Biophys. Res. Commun., 511, 330-335 (2019).
- Matsushita, N., Ishida, N., Ibi, M., Saito, M., Takahashi, M., Taniguchi, S., Iwakura, Y., Morino, Y., Taira, E., Sawa, Y., and Hirose, M. IL-1β plays an important role in pressure overoad-induced atrial fibrillation in mice. Biol. Pharm. Bull., 42, 543-546 (2019).
- Schwartz, C., Moran, T., Saunders, S. P., Kaszlikowska, A., Floudas, A., Bom, J., Nunez, G., Iwakura, Y., O’Neill, L., Irvine, A. D., McKenzie, A. N. J., Ogg, G., Walsh, P. T., Demengeot, J., and Fallon, P. G. Spontaneous atopic dermataitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. Allergy, 74, 1920-1933. (2019).
- Tang, C., Makusheva, Y., Sun, H., Han, W., and Iwakura, Y. Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors. J. Leukoc. Biol., 106, 903-917 (2019). Invited review.
- Lau, L., Porciuncula, A., Yu, A., Iwakura, Y., and David, G. Uncoupling the senescence-associated secretory phenotype from cell cycle exit via IL-1 inactivation unveils its pro-tumorigenic role. Mol. Cell Biol., 39, e00586-18 (2019).
- Drummond, R. A., Swamydas, M., Oikonomou, V., Zhai, B., Dambuza, I. M., Schaefer, B. C., Bohrer, A. C., Mayer-Barber, K. D., Lira, S. A., Iwakura, Y., Filler, S. G., Brown, G. D., Hube, B., Naglik, J. R., Hohl, T. M., and Lionakis, M. S. CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment. Nat. Immunol., 20, 559-570 (2019).
- Byk, H., Huang, G. J., Iwakura, Y., and Yarom, Y. Large scale cacium imaging of the cerebellar vermis during sensory stimulus unravels two response’s components that differ in their spatiotemporal properties. Front. Syst. Neurosci., 13, 18 (2019).
- Miyabe, C., Miyabe, Y., Moreno, L., Lian, J., Rahimi, R. A., Miura, N. N., Ohno, N., Iwakura, Y., Kawakami, T., and Luster, A. D. Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis. J. Clin. Invest., 130, 3610-3624 (2019).
- Blanco-Pérez, F., Kato, Y., Gonzalez-Menendez, I., Laiño, J., Ohbayashi, M., Burggraf, M., Krause, M., Kirberg, J., Iwakura, Y., Martella, M., Quintanilla-Martinez, L., Shibata, N., Vieths, S., Scheurer, S., and Toda, M. CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis. Sci. Rep., 9, 9608 (2019).
- Hupa, K. J., Stein, K., Schneider, R., Lysson, M., Schneiker, B., Hornung, V., Latz, E., Iwakura, Y., Kalff, J. C., and Wehner, S. AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice. Sci. Rep., 9, 10602 (2019).
- Sakurai, K., Dainichi, T., Garcet, S., Tsuchiya, S., Yamamoto, Y., Kitoh, A., Honda, T., Nomura, T., Egawa, G., Otsuka, A., Nakajima, S., Matsumoto, R., Nakano, Y., Otsuka, M., Iwakura, Y., Grinberg-Bleyer, Y., Ghosh, S., Sugimoto, Y., Guttman-Yassky, E., Krueger, J. G., and Kabashima, K. Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis. J. Allergy Clin. Immunol., 144, 1036-1049 (2019).
- Kanno, E., Tanno, H., Masaki, A., Sasaki, A., Sato, N., Goto, M., Shisai, M., Yamaguchi, K., Takagi, N., Shoji, M., Kitai, Y., Sato, K., Kasamatsu, J., Ishii, K., Miyasaka, T., Kawakami, K., Imai, Y., Iwakura, Y., Maruyama, R., Tachi, M., and Kawakami, K. Defect of interferon γ leads to impaired wound healing through prolonged neutrophilic inflammatory response and enhanced MMP-2 activation. Int. J. Mol. Sci., 20 5657 (2019).
- Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, is a potent inhibitor of hepatitis B virus.
Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Seimiya T, Suzuki T, Tanaka E, Ishibashi R, Funato K, and Koike K.
Hepatology 2019 in press. - Nakagomi R, Tateishi R, Masuzaki R, Soroida Y, Iwai T, Kondo M, Fujiwara N, Sato M, Minami T, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Tanaka Y, Otsuka M, Kato N, Moriya K, Ikeda H, Koike K. Liver stiffness measurements in chronic hepatitis C: treatment evaluation and risk assessment J Gastroenterol Hepatol. 2019 in press.
- Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.
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Nature Communications. 2019 in press. - Identification and isolation of splenic tissue resident macrophage subpopulations by flow cytometry.
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Int Immunol. 2019;31(1):51-56. - Serum aldo–keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis.
Kanno M, Kawaguchi K, Honda M, Horii R, Takatori H, Shimakami T, Kitamura K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
J Gastroenterol. 2019 Feb 1. doi: 10.1007/s00535-019-01551-3. - The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.
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Cereb Cortex. 2019 Feb 4. [Epub ahead of print] - TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity.
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Dev Cell. 2019 Jan 28;48(2):151-166.e7. - Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice.
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J Exp Med. 2019 Feb 4;216(2):267-278. - USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation.
Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, He Z, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T, Matsuura Y.
J Virol. 2019 Jan 9. pii: JVI.01708-18. - Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.
Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
Exp Mol Pathol. 2019 Feb;106:78-88. - *Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema.
Kazushige Shiraishi, Shigeyuki Shichino, Tatsuya Tsukui, Shinichi Hashimoto, Satoshi Ueha, and Kouji Matsushima
Sci Rep. in press. 2019. - Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice. Chen CY, Ueha S, Ishiwata Y, Yokochi S, Yang D, Oppenheim JJ, Ogiwara H, Shichino S, Deshimaru S, Shand FH, Shibayama S, Matsushima K.
J Immunother. in press, 2019. - A dendritic cell-based systemic vaccine induces long-lived lung-resident memory Th17 cells and ameliorates pulmonary mycosis.
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Mucosal Immunol., 12, 265-276 (2019). - Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells.
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2018年
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Cell Mol Gastroenterol Hepatol. 2018;7(2):297-312. - Inflammation and de-differentiation in pancreatic carcinogenesis.
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World J Clin Cases. 2018;6(15):882-891. - TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity.
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Dev. Cell 2018;48(2):151-166. - Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction.
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Exp. Hematol. 2018;63:41-51. - Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.
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Stem Cell Reports. 2018 Dec 11;11(6):1539-1550. - Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
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J Clin Invest. 2018 Dec 3;128(12):5603-5619. - Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.
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Cereb Cortex. 2018 Oct 11. - Ishimoto, Y., Ishibashi, K. I., Yamanaka, D., Adachi, Y., Kanzaki, K., Iwakura, Y., and Ohno, N. Production of low-molecular weight soluble yeast b-glucans by an acid degradation method.
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Biochem. Biophys. Res. Commun., 496, 934-940 (2018). - HER2 overexpression triggers an IL-1α pro-inflammatory circuit to drive tumorigenesis and promote chemotherapy resistance.
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Cancer Res., 78, 2040-2051 (2018). - Establishment and analysis ofa novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.
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Sci. Rep., 8, 2021(2018). - Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κB addiction in malignant pleural effusion.
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Nat. Commun., 9, 672 (2018). - Host defense against oral microbiota by bone-damaging T cells.
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Nat. Commun., 9, 701 (2018). - Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α deficient B cells.
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Cell. Immunol., 328, 9-17 (2018). - IL-25 enhances Th17 cell-mediated contact dermatitis by promoting IL-1β production by dermal dendreitic cells.
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J. Allergy Clin. Immunol., 142, 1500-1509 (2018). - Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells.
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PLoS One,, 13, e0195119 (2018). - A model of Th17-associated ileal hyperplasia that requires both IL-17A and IFN-γ to generate self-tolerance and prevent colitis.
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Mucosal Immunol., 11, 1127-1137 (2018). - IL-36α from skin-resident cells plays an important role in the pathogenesis of imiquimod-induced psoriasiform dermatitis by forming a local autoamplification loop.
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J. Immunol., 201, 167-182 (2018). - Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation.
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Int. J. Cardiol., 270, 221-227 (2018). - BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance.
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Sci. Adv., 4, eaas9944 (2018). - Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model.
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Microbes Infect., (2018). - MAIT cells protect agaist pulmonary Legionella longbeaches infection.
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Nat. Commun., 9, 3350 (2018). - The ATP transporter VNUT mediates induction of Dectin-1-triggered candida nociception.
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Biochem. Biophys. Res. Commun., 506, 429-436 (2018). - IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse.
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Sci. Rep., 8, 15783 (2018). - TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.
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Circulation. (2018). - Allergy inhibitory receptor-1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages.
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Int J Rheum Dis. 2018;21(12):2071-2078. - *Exploring the Gut Fungi-Lung Allergy Axis.
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Cell Host Microb. 2018;24(6):755-757. - Elovl6 regulates mechanical damage–induced keratinocyte death and skin inflammation.
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Cell Death and Diseases. 2018;9(12):1181. - Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain.
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Cell Rep. 2018;24(1):79-94. - Glycoprotein nmb is exposed on the surface of dormant breast cancer cells and induces stem cell-like properties.
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Scientific Reports. 2018;8(1):15180. - Cutting Edge: Identification of Marginal Reticular Cells as Phagocytes of Apoptotic B Cells in Germinal Centers.
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J Immunol. 2018;200(11):3691-3696. - TX99 Is a Neutralizing Monoclonal Antibody Against Mouse TIGIT.
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Monoclon Antib Immunodiagn Immunother. 2018;37(2):105-109. - Circulating concentrations of insulin resistance-associated hepatokines, selenoprotein P and leukocyte cell-derived chemotaxin 2, during an oral glucose tolerance test in humans.
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Biol Pharm Bull. 2018 Dec 28. doi: 10.1248/bpb.b18-00549. - Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.
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Sci Rep. 8(1):16727 2018 - Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits.
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Biol Pharm Bull. 41(5):828-832 2018 - Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples.
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PLoS One. 13(3):e0194798 2018 - Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice.
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Int J Mol Sci. 19(3). pii: E878 2018 - Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease.
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PLoS One. 13(1):e0191026 2018 - Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.
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Nat Commun. 9(1):30 2018. - *Asymmetric integration of single-cell transcriptomic data using latent Dirichlet allocation and Procrustes analysis
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IEEE International Conference on Bioinformatics and Biomedicine, 2129-2135, 2018. - Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism.
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Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11036-11041. - Infection with flaviviruses requires BCLXL for cell survival.
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PLoS Pathog. 2018 Sep 27;14(9):e1007299. doi: 10.1371/journal.ppat.1007299. eCollection 2018 Sep. - Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
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Int Immunol. 2018 May 24;30(6):255-265. doi: 10.1093/intimm/dxy023. - Production of low-molecular weight soluble yeast b-glucans by an acid degradation method.
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橋本真一、上羽悟史
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橋本真一
実験医学別冊 シングルセル解析プロトコール、2017年9月号 p171-175